伊曲康唑口服联合外用抗真菌药物治疗泛发性体癣的临床价值分析

Clinical value analysis of oral itraconazole combined with topical antifungal drugs in the treatment of generalized tinea corporis

目的 分析对泛发性体癣患者开展口服伊曲康唑联合外用抗真菌药物治疗的有效性。方法 50例泛发性体癣患者作为观察对象,采用双盲分组法分成参照组与治疗组,每组25例。参照组患者开展单一外用抗真菌药物治疗,治疗组患者开展伊曲康唑口服联合外用抗真菌药物治疗。对比两组患者的治疗优良率、真菌清除率、复发率、不良反应发生率、皮疹改善时间、皮疹完全消退时间及肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平。结果 治疗组患者的真菌清除率96.00%、治疗优良率92.00%明显高于参照组的72.00%、68.00%,差异具有统计学意义(P<0.05)。治疗组患者用药后的复发率4.00%显著低于参照组的24.00%,差异具有统计学意义(P<0.05);但两组用药后的不良反应发生率对比差异并不十分明显(P>0.05)。治疗组患者的皮疹改善时间(2.25±1.05)d、皮疹完全消退时间(6.57±2.06)d明显短于参照组的(3.69±1.12)、(9.79±2.63)d, TNF-α(1.52±0.40)μg/L、CRP(25.15±3.26)mg/L均低于参照组的(1.92±0.41)μg/L、(29.53±3.30)mg/L,差异具有统计学意义(P<0.05)。结论 口服伊曲康唑+外用抗真菌药物治疗泛发性体癣的安全性及有效性均较高,能在短时间内改善皮疹症状,减少疾病复发,促进患者预后。

Objective To analyze the effectiveness of oral itraconazole combined with topical antifungal drugs in the treatment of generalized tinea corporis.Methods 50 patients with generalized tinea corporis were studied and divided into a reference group and a treatment group by double-blind grouping method,with 25 cases in each group.The reference group was treated with topical antifungal drugs alone,and the treatment group was treated with oral itraconazole and topical antifungal drugs.Comparison was made on excellent rate of treatment,fungal clearance rate,recurrence rate,incidence of adverse reactions,time of rash improvement,time of rash complete resolution,and the levels of tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)between the two groups.Results The treatment group had fungal clearance rate of 96.00%and excellent rate of treatment of 92.00%,which were significantly higher than 72.00%and 68.00%in the reference group,and the differences were statistically significant(P<0.05).The treatment group had significantly lower recurrence rate of 4.00%than 24.00%in the reference group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The time of rash improvement and time of rash complete resolution in the treatment group were(2.25±1.05)and(6.57±2.06)d,which were significantly shorter than(3.69±1.12)and(9.79±2.63)d in the reference group;the treatment group had TNF-αof(1.52±0.40)μg/L and CRP of(25.15±3.26)mg/L,which were lower than(1.92±0.41)μg/L and(29.53±3.30)mg/L in the reference group;the difference was statistically significant(P<0.05).Conclusion Oral itraconazole and topical antifungal drugs are safe and effective in the treatment of generalized tinea corporis,which can improve rash symptoms in a short time,reduce disease recurrence and promote the prognosis of patients.