儿童难治性癫痫术后认知功能变化的研究进展

Advances in postoperative cognitive changes in children with refractory epilepsy

难治性癫痫儿童常伴有不同程度的认知功能障碍,部分患儿需进行癫痫外科手术治疗。随访研究儿童难治性癫痫术后认知功能的变化情况,有助于术前辅助临床决策。多项研究结果显示,术后多数患儿整体认知功能发展较术前无下降甚至改善,术前智商/发育商水平、抗癫痫药物数量及癫痫发作等多因素与术后认知功能预后相关。本文综述儿童难治性癫痫术后认知功能研究进展。

Children with refractory epilepsy often experience varying degrees of cognitive dysfunction,and some may require epileptic surgery.Follow-up studies on the changes in cognitive function after surgery in children with refractory epilepsy are beneficial for assisting preoperative clinical decisions.Multiple research findings indicate that,in the majority of cases,the overall cognitive function in children tends to either remain stable or improve after surgery,as compared to preoperative levels.Factors such as preoperative IQ/DQ levels,the quantity of antiepileptic drugs used,and the severity of epileptic seizures are associated with the prognosis of cognitive function postoperatively.This article reviews the research progress on postoperative cognitive function in children with refractory epilepsy.