振荡筛孔雾化在机械通气患者中的应用

Application of oscillating sieve atomization in patients undergoing mechanical ventilation

目的分析机械通气患者的雾化给药中实施振荡筛孔雾化装置给药对于患者呼吸系统状态的影响。方法选取2020年9月至2022年12月赣南医学院附属兴国医院重症医学科实施机械通气支持的62例呼吸系统疾病患者作为研究对象,依据奇偶数法分为对照组和观察组,每组各31例。对照组实施常规氧气雾化给药,观察组实施振荡筛孔雾化给药。比较两组患者不同给药方案下呼吸参数、雾化指标、血气指标、血清炎症指标。结果观察组治疗后潮气量、动态顺应性均高于对照组,气道峰压、呼吸频率低于对照组,差异有统计学意义(P<0.05);观察组患者的雾化准备时间、雾化给药时间、雾化给药残余量短于对照组,雾化后呼吸机报警次数均低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的氧分压、氧合指数、酸碱度值高于对照组,二氧化碳分压、呼吸频率低于对照组,两组患者治疗后的氧分压、氧合指数、酸碱值高于治疗前,二氧化碳分压、呼吸频率低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的白介素-13、降钙素原、人可溶性细胞间黏附分子、粒细胞-巨噬细胞集落刺激因子、C反应蛋白低于对照组,两组患者治疗后的炎症指标低于治疗前,差异有统计学意义(P<0.05)。结论机械通气患者的雾化给药中实施振荡筛孔雾化装置给药可提升给药效能,缩短给药时间,改善患者的呼吸指标,促进患者的炎症消退,具有重要应用价值。

Objective To analyze the impact of implementing an oscillating sieve atomization device in the nebulization ad-ministration of mechanically ventilated patients on their respiratory system status.Methods A total of 62 patients with res-piratory diseases who underwent mechanical ventilation support in the Department of Critical Care Medicine,Xingguo Hos-pital Affiliated to Gannan Medical College from September 2020 to December 2022 were selected as the study objects,and they were divided into control group and observation group according to the odd-even method,with 31 patients in each group.The control group received conventional oxygen drive atomization medication,while the observation group received oscillating sieve atomization medication.The respiratory parameters,atomization indicators,and blood gas indicators of the two groups of patients were compared under different medication regimens Serum inflammatory markers.Results The tidal volume and dynamic compliance of the observation group were higher than those of the control group,and the airway peak pressure and respiratory rate were lower than those ofthe control group,and the differences were statistically significant(P<0.05).The atomization preparation time,atomization administration time,residual amount of atomization administration,and ventilator alarm times after atomization in the observation group were lower than those in the control group(P<0.05).The ar-terial partial pressure of oxygen,oxygenation index and pH value of the observation group after treatment were higher than those of the control group,while arterial partial pressure of carbon dioxide and respiratory rate were lower than those of the control group,the arterial partial pressure of oxygen,oxygenation index and pH value of the two groups afer treatment were higher than those before treatment,while arterial partial pressure of carbon dioxide and respiratory rate were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of interleukin-13,procalcitonin,hu-man soluble intercellular adhesion molecule,granulo-cyte-macrophage colony-stimulating factor,C-reactive protein in the observation group after treatment were lower than those in the control group,and the inflammatory indexes in the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05).Conclusion The implementation of an oscillating sieve at-omization device in the atomization administration of mechanically ventilated patients can enhance the efficacy of the medi-cation,shorten the administration time,improve the patient's respiratory indicators,and promote the regression of inflamma-tion,which has important application value.