circRNA-miRNA在牙髓炎和根尖周炎中的作用

The significance of circRNA-miRNA in pulpitis and apical periodontitis

牙髓炎和根尖周炎是牙髓病的两个发展阶段,前者是发生在牙髓组织中的炎症反应,后者则是牙髓炎进一步进展后刺激根尖周组织所发生的炎症疾病。炎症的发生使患者疼痛明显,可伴咬合疼痛,影响进食,长此以往,影响全身健康,严重降低生活质量。circRNA是一类具有生物活性的核酸分子,属于内源性RNA,而miRNA是由发夹前体加工合成的高度保守的单链RNA序列,二者广泛存在于生物体内。circRNA具有互补的miRNA结合位点,可作为miRNA海绵,通过竞争性内源RNA机制,调控下游靶基因的表达,与机体炎症性疾病的发生密切相关,circRNA可调控牙髓干细胞,凋亡和炎症反应,促进其成骨分化;而miRNA已被证实在根尖周炎的发病机制中发挥着重要作用。本综述通过阐述circRNA-miRNA广泛参与机体众多炎症反应,阐明牙髓炎和根尖周炎中miRNA和circRNA所起到的作用,希望为开发新的预防、诊断及治疗方法提供依据。

Pulpitis and apical periodontitis are two stages of development of dental pulp disease.The former is an inflammatory reaction that occurs in the pulp tissue,while the latter is an inflammatory disease that stimulates the periapical tissue after further progression of pulpitis.The occurrence of inflammation causes significant pain in patients,which can be accompanied by bite pain and affect eating.Over time,it can affect overall health and seriously reduce quality of life.CircRNA is a type of biologically active nucleic acid molecule that belongs to endogenous non coding RNA,while miRNA is a highly conserved single stranded RNA sequence synthesized by processing hair clip precursors,both of which are widely present in organisms.CircRNA has complementary miRNA binding sites and can serve as a miRNA sponge.Through competitive endogenous RNA mechanisms,it regulates the expression of downstream target genes and is closely related to the occurrence of inflammatory diseases in the body.CircRNA can regulate dental pulp stem cells,apoptosis,and inflammatory response,promoting their osteogenesis and differentiation;And miRNA has been confirmed to play an important role in the pathogenesis of apical periodontitis.This review elucidates the widespread involvement of circRNA miRNA in numerous inflammatory reactions in the body,elucidates the role of miRNA and circRNA in pulpitis and periapical periodontitis,and hopes to provide a basis for the development of new prevention,diagnosis,and treatment methods.