丹参-红花配伍抗脑缺血再灌注损伤的机制研究进展

Research Progress on Mechanism of the Combination of Salvia Miltiorrhiza and Safflower Against Cerebral Ischemia-reperfusion Injury

脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI)是指当脑缺血一定时间再恢复血液供应后,其功能未恢复,反而导致更加严重的脑功能障碍。CIRI是缺血性脑卒中的共同特征和病理生理机制,其主要通过脑神经元兴奋性氨基酸毒性增强、氧自由基损伤、钙超载、炎症反应以及细胞凋亡等途径造成神经细胞损伤。当前,现代医学防治CIRI的重要手段是静脉溶栓。然而,CIRI具有发病急、治疗时间窗短、预后差的特点,治疗手段具有局限性。中药丹参-红花配伍具有抗CIRI的作用,临床疗效较好;其作用机制可能是促进血管新生、抗细胞凋亡等效应。本综述以血管稳态为切入点,总结了中药丹参-红花配伍抗CIRI的生物学机制,为后续相关实验及临床研究提供一定的理论依据。

Cerebral ischemia reperfusion injury(CIRI)refers to the inability to restore blood supply after a certain period of cerebral ischemia,leading to more severe brain dysfunction.CIRI is a common feature and pathophysiological mechanism of ischemic stroke,which mainly causes neuronal damage through pathways such as increased excitatory amino acid toxicity in brain neurons,oxygen free radical damage,calcium overload,inflammatory response,and cell apoptosis.The latest research suggests that CIRI’s prevention and treatment methology is intravenous thrombolysis.However,CIRI is characterized by short treatment time windows and unfavorable prognosis due to the limitation.The combination of traditional Chinese medicine salvia miltiorrhizo and safflower has the effect of anti-CIRI,and good clinical efficacy.Its mechanism may be revalent to promote angiogenesis,anti-apoptosis and other effects.Taking vascular homeostasis as the starting key point,the paper discusses the biological mechanism of the combination of traditional Chinese medicine salvia miltiorrhizo and safflower in treating CIRI,providing a certain theoretical basis for subsequent related experiments and clinical studies.