叶酸水平与美国65岁以上老年男性良性前列腺增生的关联性分析

Association Between Folic Acid Level and Benign Prostatic Hyperplasia in American Men Over 65 Years Old

目的:良性前列腺增生(BPH)是中老年男性常见病,叶酸水平可能与年龄有关。因此,本研究旨在分析叶酸与BPH之间的关系。方法:选取美国国家健康与营养检查调查(NHANES)数据库2001—2008年数据,根据既往研究,将叶酸按照五分位法分为Q1~Q5五组,用统计软件R和Free statistics进行多因素Logistic回归分析和亚组分析。结果:研究最终纳入886名参与者,其中690例(77.9%)患有良性前列腺增生,平均年龄(68.1±10.6)岁。分析显示,在调整了潜在的混杂因素后,与最低五分位(Q1)相比,高水平血清叶酸和红细胞叶酸与BPH发生风险增加相关(OR=2.07,95%CI:1.14~3.75,P=0.016;OR=1.73,95%CI:1.01~2.96,P=0.047),而膳食叶酸没有(OR=1.36,95%CI:0.78~2.38,P=0.279)。亚组分析显示,在年龄>65岁的亚组中,高水平血清叶酸和红细胞叶酸与BPH发生风险增加相关(OR=2.38,95%CI:1.2~4.74,P=0.014;OR=2.31,95%CI:1.22~4.39,P=0.01)。结论:在美国老年男性个体中,高水平血清叶酸和红细胞叶酸可能是BPH的危险因素。

【Objective】Benign prostatic hyperplasia(BPH)is a common disease in middle-aged and elderly men,and folate level may be related to age.Therefore,this study aimed to analyze the relationship between folate and BPH.【Method】The data of NHANES population in the United States from 2001 to 2008 were selected.According to previous studies,folic acid was divided into five groups(Q1~Q5),and multivariate logistic regression analysis and subgroup analysis were performed by statistical software R and Free statistics.【Result】The study included 886 participants,of whom 690(77.9%)had BPH with a mean age of(68.1±10.6)years.Analysis showed that,after adjusting for potential confounding factors,higher serum and RBC folate levels were associated with an increased risk of BPH compared with the lowest quintile(Q1)(OR=2.07,95%CI:1.14—3.75,P=0.016;OR=1.73,95%CI:1.01—2.96,P=0.047),and dietary folic acid was not(OR=1.36,95%CI:0.78—2.38,P=0.279).Subgroup analysis showed that high levels of serum and RBC folate were associated with an increased risk of BPH in subgroups aged>65 years(OR=2.38,95%CI:1.2—4.74,P=0.014;OR=2.31,95%CI:1.22—4.39,P=0.01).【Conclusion】In individual elderly men in the United States,high levels of serum and erythrocyte folic acid may be risk factors for BPH.