中医情志联合个性化干预对晚期乳腺癌新辅助化疗患者体液免疫和生存质量的影响

Influence of traditional Chinese medicine emotions combined with individualized interventions on humoral immunity and quality of life of advanced breast cancer patients undergoing neoadjuvant chemotherapy

目的探讨晚期乳腺癌新辅助化疗患者采用中医情志联合个性化干预对患者体液免疫和生存质量的影响。方法纳入河北省沧州中西医结合医院2022年收治的晚期乳腺癌新辅助化疗患者120例作为研究对象,随机分为对照组和研究组,每组60例。对照组采用常规护理干预,研究组实施中医情志联合个性化干预,比较2组的干预效果。结果2组干预后体液免疫功能的相关指标水平均较干预前显著下降,但研究组的下降幅度低于对照组(P<0.05)。2组干预后应激反应的相关指标水平均较干预前显著升高,但研究组的升高幅度低于对照组(P<0.05)。2组干预后的焦虑、抑郁评分较之干预前均降低,研究组低于对照组(P<0.05)。2组生存质量评分较之干预前均升高,且研究组高于对照组(P<0.05)。研究组干预满意度为96.67%,高于对照组的80.00%(P<0.05)。结论晚期乳腺癌新辅助化疗患者采用中医情志联合个性化干预,可降低患者的应激反应,缓解不良情绪,提升患者的生存质量和免疫功能,患者的护理满意度高。

Objective To explore the effect of the traditional Chinese medicine(TCM)emotions combined with individualized interventions on humoral immunity and quality of life of advanced breast cancer patients undergoing neoadjuvant chemotherapy.Methods A total of 120 advanced breast cancer patients treated with neoadjuvant chemotherapy in Cangzhou Hospital of Integrated TCM-WM Hebei in 2022 were enrolled as the study subjects.They were randomly divided into the control group and research group,with 60 cases in each group.Patients in the control group received routine nursing intervention,while those in the research group received individualized interventions combined with TCM emotions.Intervention effects of the two groups were compared.Results After the interventions,humoral immunity levels in both groups were significantly lower than those before the interventions,but the declines in the research group were significantly greater than those of control group(P<0.05).After the interventions,stress response levels in both groups were significantly higher than those before the interventions,but the elevations in the research group were significantly less than those of control group(P<0.05).After the interventions,the anxiety and depression scores of both groups significantly decreased compared to those before intervention,which were significantly lower in the research group than those of control group(P<0.05).The quality of life scores of both groups increased compared to before interventions,which were significantly higher in the research group than those of the control group(P<0.05).The satisfaction rate with intervention in the research group was significantly higher than that of control group(96.67%vs 80.00%,P<0.05).Conclusion The combination of TCM emotions and individualized interventions for advanced breast cancer patients treated with neoadjuvant chemotherapy can reduce the stress response,alleviate bad emotions,improve the quality of life and immune function,and with a high nursing satisfaction.