Epstein-Barr病毒与肝损伤相关性的研究进展

Research progress on Epstein-Barr virus-related liver injury

EB病毒(Epstein-Barr Virus,EBV)作为常见的非嗜肝DNA病毒之一,早已被研究证实可以导致肝脏损伤(Liver injury)并引起肝功能异常,且已成为临床医生对肝功能异常患者筛查的重要指标之一。但目前尚缺乏对既往有关其感染所致肝损伤的研究成果的有效整合。本文通过梳理相关文献系统、全面探讨EBV与肝损伤相关性的研究进展,包括EBV概述、感染的现状、传播方式、所致疾病类型、其致肝损伤可能的机制和对临床诊疗的影响及EBV相关性肝损伤未来的研究方向。本文表明EBV感染所致肝损伤可能持续存在并导致严重后果,为全球带来巨大的疾病负担。因此,临床医生必须对其予以足够的重视,以期早期识别,并尽早采取有效措施使患者能最大获益。

Epstein-Barr Virus(EBV),a common non-hepatophil DNA viruses,has long been confirmed to cause liver injury and liver abnormalities,and it has become an important indicators for clinicians to screen patients with liver function abnormalities.However,There is a lack of effective integration in the past research results of EBV-related liver injury.This systematic paper comprehensively discussed the research progress of EBV-related liver injury by combing relevant literature,including the overview of EBV,infection status,transmission mode,disease types,the possible mechanism of liver injury and its influence on clinical diagnosis and treatment,as well as the future research direction of EBV-related liver injury.This study suggests that EBV-related liver damage might be persistent and have serious consequences,resulting in a significant global disease burden.Therefore,clinicians must pay enough attention for identifying it early,and taking effective measures as soon as possible to maximize the benefit of patients.