丁苯酞联合低分子肝素对急性进展性脑梗死患者血液流变学及神经功能的影响

Effects of butylphthalide combined with low molecular weight heparin on hemorheology and neurological function in patients with acute progressive cerebral infarction

目的探讨丁苯酞联合低分子肝素对急性进展性脑梗死患者血液流变学及神经功能的影响。方法选取2020年1月至2023年1月我院收治的60例急性进展性脑梗死患者为研究对象,按照随机数字表法将其分为对照组和观察组,各30例。对照组给予低分子肝素治疗,观察组在对照组基础上给予丁苯酞治疗。比较两组的临床疗效、炎症因子水平、血管内皮功能指标、血液流变学、神经功能及日常生活能力。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)水平、全血高切黏度、全血低切黏度、血浆比黏度、纤维蛋白原及美国国立卫生院卒中量表(NIHSS)评分均降低,一氧化氮(NO)水平及日常生活能力量表(ADL)评分均升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。结论丁苯酞联合低分子肝素治疗急性进展性脑梗死患者的效果显著,能改善患者的血液流变学及血管内皮功能,减轻炎症反应,提高神经功能及日常生活能力。

Objective To investigate the effects of butylphthalide combined with low molecular weight heparin on hemorheology and neurological function in patients with acute progressive cerebral infarction.Methods A total of 60 patients with acute progressive cerebral infarction admitted in our hospital from January 2020 to January 2023 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 30 cases in each group.The control group was treated with low molecular weight heparin,and the observation group was treated with butylphthalide on the basis of the control group.The clinical efficacy,inflammatory factor levels,vascular endothelial function indexes,hemorheology,neurological function and daily living ability were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),homocysteine(Hcy),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),whole blood high shear viscosity,whole blood low shear viscosity,plasma specific viscosity,fibrinogen,and the National Institutes of Health Stroke Scale(NIHSS)score in the two groups decreased,the level of nitric oxide(NO)and Activities of Daily Living(ADL)score increased,and those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide combined with low molecular weight heparin is effective in the treatment of patients with acute progressive cerebral infarction.It can improve the hemorheology and vascular endothelial function of patients,reduce the inflammatory response,and improve the neurological function and daily living ability.