玉屏风散加减辅助卡介菌多糖核酸注射液治疗过敏性皮炎患者的效果及对T淋巴细胞亚群水平的影响

Effect of modified Yupingfeng powder assisted BCG polysaccharide and nucleic acid injection in the treatment of patients with allergic dermatitis and its influences on the levels of T lymphocyte subsets

目的探讨玉屏风散加减辅助卡介菌多糖核酸注射液治疗过敏性皮炎患者的效果。方法选择2019年3月至2022年3月就诊于医院的150例过敏性皮炎患者,以随机数字表法将其分为A组和B组,各75例。A组给予卡介菌多糖核酸注射液治疗,B组在A组治疗基础上行玉屏风散加减治疗。比较两组的治疗效果。结果B组的治疗总有效率高于A组,随访3个月内复发率低于A组(P<0.05)。治疗后,两组的CD3^(+)、CD4^(+)高于治疗前,CD8^(+)低于治疗前,且B组优于A组(P<0.05)。B组的瘙痒消失时间、皮疹消失时间短于A组(P<0.05)。治疗后,两组的皮肤病生活质量指数(DLQI)评分低于治疗前,且B组低于A组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论玉屏风散加减辅助卡介菌多糖核酸注射液治疗过敏性皮炎患者的效果显著,能减少病情复发,改善T淋巴细胞亚群水平,加速症状消失,且提高其生活质量。

Objective To explore the effect of modified Yupingfeng powder assisted BCG polysaccharide and nucleic acid injection in the treatment of patients with allergic dermatitis.Methods A total of 150 patients with allergic dermatitis who were treated in hospital from March 2019 to March 2022 were selected and divided into group A and group B according to the random number table method,with 75 cases in each group.The group A was treated with BCG polysaccharide and nucleic acid injection,and the group B was treated with modified Yupingfeng powder on the basis of the group A treatment.The therapeutic effects were compared between the two groups.Results The total effective rate of treatment in the group B was higher than that in the group A,and the recurrence rate within 3 months of follow-up was lower than that in the group A(P<0.05).After treatment,the CD3^(+)and CD4^(+)in the two groups were higher than those before treatment,the CD8^(+)was lower than that before treatment,and those of the group B were better than the group A(P<0.05).The disappearance time of pruritus and rash in the group B were shorter than those in the group A(P<0.05).After treatment,the score of Dermatology Life Quality Index(DLQI)in the two groups was lower than that before treatment,and that in the group B was lower than the group A(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The modified Yupingfeng powder assisted BCG polysaccharide and nucleic acid injection in the treatment of patients with allergic dermatitis can reduce the recurrence of the disease,improve the levels of T lymphocyte subsets,accelerate the disappearance of symptoms,and improve their quality of life.