脓毒症免疫抑制机制的研究进展

Research progress on immunosuppressive mechanism of sepsis

脓毒症是机体因感染产生免疫反应失调导致器官功能障碍的综合征,其发病率和死亡率均较高。脓毒症免疫反应的病理生理通常分为急性炎症反应和随后的免疫抑制两个阶段,脓毒症并发的免疫抑制使患者容易受到医院和机会性感染的影响,造成脓毒症患者住院时间延长和晚期死亡增加。脓毒症免疫抑制发病机制复杂多样,深入了解其发病机制可以帮助临床及时发现患者的免疫抑制风险,以便进行针对性治疗,从而改善脓毒症患者的预后。本文就脓毒症免疫抑制发病机制进行综述。

Sepsis is a syndrome of organ dysfunction caused by immune response disorder caused by infection,with high morbidity and mortality.The pathophysiology of sepsis immune response is usually divided into two stages:acute inflammatory response and subsequent immunosuppression.The immunosuppression complicated by sepsis makes patients vulnerable to hospital and opportunistic infections,resulting in prolonged hospital stay and increased late death in patients with sepsis.The pathogenesis of sepsis immunosuppression is complex and diverse.In-depth understanding of its pathogenesis can help timely detect the risk of immunosuppression in patients in clinic,so as to carry out targeted treatment and improve the prognosis of patients with sepsis.This article reviews the pathogenesis of sepsis immunosuppression.