单球囊双侧序贯扩张经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折的效果及对炎性反应、椎体复位情况的影响

Effect of single balloon bilateral sequential expansion percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures and its influences on inflammatory response and vertebral reduction

目的探讨单球囊双侧序贯扩张经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折的效果及对炎性反应、椎体复位情况的影响。方法选取2021年1月至2022年1月收治的80例骨质疏松性椎体压缩性骨折患者为研究对象,根据术式差异将其分为对照组和观察组,各40例。对照组采用单球囊单侧扩张经皮椎体后凸成形术治疗,观察组采用单球囊双侧序贯扩张经皮椎体后凸成形术治疗。比较两组的治疗效果。结果观察组的手术时间长于对照组,骨水泥注入量、骨水泥弥散系数高于对照组(P<0.05)。术后,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。术后,观察组的椎体前缘高度大于对照组,Cobb角小于对照组(P<0.05)。术后,观察组的Leptin、Ⅰ型前胶原氨基端前肽(PⅠNP)水平均低于对照组(P<0.05)。结论单球囊双侧序贯扩张经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折虽会增加手术时间,但可提高骨水泥注入量、骨水泥弥散系数,减轻炎性反应,提升椎体复位效果,下调Leptin、PⅠNP水平,值得推广。

Objective To investigate the effect of single balloon bilateral sequential expansion percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures and its influences on inflammatory response and vertebral reduction.Methods A total of 80 patients with osteoporotic vertebral compression fractures admitted from January 2021 to January 2022 were selected as the research objects.According to the difference of operation methods,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with single balloon unilateral dilatation percutaneous kyphoplasty,and the observation group was treated with single balloon bilateral sequential expansion percutaneous kyphoplasty.The therapeutic effects of the two groups were compared.Results The operation time of the observation group was longer than that of the control group,and the bone cement injection volume and bone cement dispersion coefficient were higher than those of the control group(P<0.05).After operation,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).After operation,the anterior vertebral height of the observation group was bigger than that of the control group,and the Cobb angle was smaller than that of the control group(P<0.05).After operation,the levels of Leptin and procollagen typeⅠN-terminal propeptide(PⅠNP)in the observation group were lower than those in the control group(P<0.05).Conclusion Single balloon bilateral sequential expansion percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures will increase the operation time,but it can increase the bone cement injection volume and bone cement dispersion coefficient,reduce the inflammatory response,improve the effect of vertebral reduction,and down-regulate the levels of Leptin and PⅠNP,which is worthy of promotion.