六味补肺益肾汤剂联合沙美特罗替卡松粉吸入剂对支气管哮喘患者症状改善及生活质量的影响

Effects of Liuwei Bufei Yishen decoction combined with salmeterol xinafoate and fluticasone propionate powder for inhalation on symptom improvement and quality of life in patients with bronchial asthma

目的探究六味补肺益肾汤剂联合沙美特罗替卡松粉吸入剂对支气管哮喘患者症状改善及生活质量的影响。方法选取2021年10月至2022年11月收治的150例支气管哮喘患者为研究对象,按照随机数字表法将其分为对照组和观察组,各75例。对照组采用沙美特罗替卡松粉吸入剂治疗,观察组在对照组基础上联合六味补肺益肾汤剂治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的哮喘控制测试问卷(ACT)评分、CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均升高,圣乔治呼吸问卷(SGRQ)评分、中医证候积分、肿瘤坏死因子-α(TNF-α)、白细胞介素-5(IL-5)、白细胞介素-18(IL-18)水平及CD8^(+)均降低,且观察组优于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论六味补肺益肾汤剂联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的效果显著,可缓解临床症状,减轻炎症反应,提高免疫功能,改善生活质量。

Objective To explore the effects of Liuwei Bufei Yishen decoction combined with salmeterol xinafoate and fluticasone propionate powder for inhalation on symptom improvement and quality of life in patients with bronchial asthma.Methods A total of 150 patients with bronchial asthma admitted from October 2021 to November 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 75 cases in each group.The control group was treated with salmeterol xinafoate and fluticasone propionate powder for inhalation,and the observation group was treated with Liuwei Bufei Yishen decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the Asthma Control Test(ACT)score,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups increased,while the Saint George's Respiratory Questionnaire(SGRQ)score,TCM syndrome score,tumor necrosis factor-α(TNF-α),interleukin-5(IL-5)and interleukin-18(IL-18)levels and CD8^(+)decreased,and those in the observation group were better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Liuwei Bufei Yishen decoction combined with salmeterol xinafoate and fluticasone propionate powder for inhalation has a significant effect on bronchial asthma,which can relieve clinical symptoms,reduce inflammation,elevate immune function and improve quality of life.