450例糖耐量减低患者中医体质分布及相关影响因素

Distribution of traditional Chinese medicine constitution and related influential factors in 450 patients with impaired glucose tolerance

目的研究糖耐量减低(IGT)患者的中医体质分布及相关影响因素。方法采用横断面研究方法,收集2021年1月—2021年8月就诊于全国8家协作单位的IGT患者。纳入符合要求的研究对象后记录基本信息,完善体格检查及实验室检查,并依据“中医体质分类与判定表”进行体质资料的收集。最后将患者信息录入Excel表,利用SPSS 26.0统计软件分析数据。结果450例研究对象中,体质分布以平和质(37.3%)、阳虚质(15.6%)、痰湿质(14.4%)和湿热质(10.9%)为主。其中在偏颇体质分布中,男性湿热质占比明显高于女性,女性阳虚质和血瘀质占比明显高于男性(P<0.05);痰湿质患者的甘油三酯水平高于阳虚质(P<0.05),阳虚质患者的高密度脂蛋白胆固醇水平高于痰湿质(P<0.05),痰湿质、湿热质、阴虚质患者的尿酸水平高于阳虚质,且以湿热质最高(P<0.05)。结论IGT患者的中医体质分布以平和质、阳虚质、痰湿质和湿热质为主,性别、血脂及尿酸情况是影响IGT患者体质状况的主要因素。

Objective We aimed to study the distribution of traditional Chinese medicine(TCM)constitution and related influencing factors in patients with impaired glucose tolerance(IGT).Methods A cross⁃sectional study method was used to enroll IGT patients who attended one of eight collaborating units across China between January and August 2021.Basic information was recorded,physical and laboratory examinations were completed,and the data on TCM constitution were collected according to the"classification and determination table of TCM constitution."Finally,patient information was entered into an Excel table,and the data were analyzed using SPSS 26.0.Results Among the 450 patients,a balanced constitution accounted for 37.3%,yang⁃deficiency constitution for 15.6%,phlegm⁃dampness constitution for 14.4%,and dampness⁃heat constitution for 10.9%.Among the biased constitutions,the proportion of men with dampness⁃heat constitution was higher than that of women,and the proportion of women with yang⁃deficiency constitution and blood stasis constitution was significantly higher than that of men(P<0.05).The triglyceride level of patients with phlegm⁃dampness constitution was higher than that of patients with yang⁃deficiency constitution(P<0.05);the HDL⁃cholestrol level of patients with yang⁃deficiency constitution was higher than that of patients with phlegm⁃dampness constitution(P<0.05);and the uric acid level of patients with phlegm⁃dampness constitution,dampness⁃heat constitution,or yin⁃deficiency constitution was higher than that of patients with yang⁃deficiency constitution,and the UA level was the highest in patients with dampness⁃heat constitution(P<0.05).Conclusion The distribution of TCM constitution in IGT patients was dominated by balanced constitution,followed by yang⁃deficiency constitution,phlegm⁃dampness constitution,and dampness⁃heat constitution.Gender,blood lipid levels,and UA levels were the main factors affecting the constitution status of IGT patients.