胸腺肽α1联合FOLFOX4化疗方案治疗老年中晚期胃癌患者的效果

Effect of thymopeptideα1 combined with FOLFOX4 chemotherapy regimen in the treatment of elderly patients with advanced gastric cancer

目的探究胸腺肽α1联合FOLFOX4化疗方案治疗老年中晚期胃癌患者的效果。方法选取102例老年胃癌患者作为研究对象,并将其随机分为常规组和观察组,每组51例。常规组采用FOLFOX4化疗方案,观察组在常规组治疗方案基础上加用胸腺肽α1,两组均接受3个周期的治疗。比较两组治疗后总有效率,治疗前后血清细胞角质蛋白19片段抗原21⁃1(CYFRA 21⁃1)、癌胚抗原(CEA)、组织多肽特异抗原(TPS)、趋化因子(C⁃C基元)配体5(CCL5)、组织金属蛋白酶抑制剂(TIMP⁃1)、基质金属蛋白酶(MMP)⁃9、MMP⁃2水平、CD3+、CD4+和CD4+/CD8+比值,以及治疗期间毒副反应的发生情况。结果治疗3个周期后,观察组治疗总有效率高于常规组,血清CYFRA 21⁃1、CEA、TPS、CCL5、TIMP⁃1、MMP⁃9、MMP⁃2水平均低于常规组,血清CD3+、CD4+水平与CD4+/CD8+比值均高于常规组(均P<0.05)。观察组治疗期间胃肠道反应、肝功能异常、神经毒性、骨髓抑制毒副反应的发生率均低于常规组(均P<0.05)。结论胸腺肽α1联合FOLFOX4化疗方案治疗老年胃癌患者疗效确切,可有效地改善患者的免疫功能,降低肿瘤标志物水平和肿瘤细胞侵袭能力,减少毒副反应的发生。

Objective To investigate the effect of thymopeptideα1 combined with FOLFOX4 chemotherapy regimen in the treatment of elderly patients with advanced gastric cancer.Methods A total of 102 elderly patients with gastric cancer were selected as the study subjects and randomly divided into a conventional group or an observation group,with 51 cases in each group.The conventional group was treated with FOLFOX4 chemotherapy regimen,based on which the observation group was treated with thymopeptideα1 additionally,and both groups received 3 cycles of treatment.The total effective rate after treatment,serum cytokeratin 19 fragment antigen 21-1(CYFRA 21-1),carcinoembryonic antigen(CEA),tissue polypeptide specific antigen(TPS),chemokine(C-C motif)ligand 5(CCL5),tissue inhibitor of metalloproteinase(TIMP)-1,matrix metalloproteinase(MMP)-9,MMP-2,CD3+,and CD4+levels and CD4+/CD8+ratio before and after treatment,and the occurrence of toxic and side effects during treatment were compared between the two groups.Results After 3 cycles of treatment,in the observation group,the total effective rate of treatment was higher than that in the conventional group,the serum levels of CYFRA 21-1,CEA,TPS,CCL5,TIMP-1,MMP-9,and MMP-2 were lower than those in the conventional group,and the serum CD3+and CD4+levels and the CD4+/CD8+ratio were higher than those in the conventional group(all P<0.05).The incidences of toxic and side effects during treatment,such as gastrointestinal reactions,abnormal liver function,neurotoxicity,and myelosuppression in the observation group were lower than those in the conventional group(all P<0.05).Conclusion Thymopeptideα1 combined with FOLFOX4 chemotherapy regimen has a definite curative effect on elderly patients with gastric cancer,which can effectively improve patients'immune function,reduce their tumor markers levels and tumor cell invasion ability,and lower the incidences of toxic and side effects.