BMI1分子调控肿瘤干细胞自我更新及免疫逃逸的作用机制

Regulation and its mechanisms of BMI1 molecule on self-renewal and tumor immune evasion of cancer stem cells

B细胞特异性莫洛尼鼠白血病病毒整合位点1(BMI1)分子属于多梳家族(PcG)成员,作为重要的干细胞标志物之一,通过转录调控基因的表达维持机体的正常生理功能。研究报道,BMI1也是影响恶性肿瘤发生发展的关键分子,在肿瘤干细胞(CSCs)的自我更新、迁移侵袭、耐药及免疫逃逸中发挥重要的调控作用,参与肿瘤的复发、转移等过程。本文总结近年的研究进展,阐述BMI1的分子结构和生物学功能,分析BMI1分子对CSCs自我更新、迁移侵袭、耐药及免疫逃逸的调控作用,探讨BMI1作为新型靶点在肿瘤免疫治疗中的潜在价值。

B-cell-specific moloney murine leukemia virus integration site 1(BMI1)molecule is one of the members of the family of the Polycomb group(PcG)protein.As a crucial marker of stem cells,it maintains the normal physiological functions of the organisms through regulating expression of the related genes transcriptionally.It was reported that BMI1 is also a crucial molecule which affects pathogenesis and progression of malignant tumors.Therefore,it plays an important role in regulating self-renewal,migration,invasion,drug-resistance,and as well as immune evasion of cancer stem cells(CSCs),which is associated with recurrence and metastasis of cancer.In this review,based on the research progresses during recent years,molecular structure and biological function of BMI1 were illustrated.Furthermore,regulation and its mechanisms of BMI1 molecule on the self-renewal,migration and invasion,drug-resistance and immune evasion of CSCs were also elaborated.It indicated that investigation of BMI1 molecule as a novel potential target in cancer immunotherapy would be much valuable and significant.