摘要
胃癌居全球肿瘤死因第三位,总生存率低,治疗预后差。幽门螺杆菌(Helicobacter pylori,H.pylori)是胃癌发生的主要原因之一,世界上一半人口感染H.pylori。H.pylori感染也是胃癌前病变(precancerous lesions of gastric cancer,PLGC)发生的重要原因,PLGC与胃癌发生密切相关,在病变早期阶段,延缓或逆转PLGC则成为治疗和预防胃癌的关键。本文综述了PLGC的进展过程中根除H.pylori的重要性及有效性,旨在为临床治疗提供更多参考。
Gastric cancer is the third leading cause of cancer death in the world,with a low overall survival rate and a poor prognosis.H.pylori is one of the main causes of gastric cancer.Half of the world′s population is infected with H.pylori.H.pylori infection is also an important cause of precancerous lessions of gastric cancer(PLGC).PLGC is closely related to the occurrence of gastric cancer.In the early stage of gastric lesions,delaying or reversing PLGC is the key to the treatment and prevention of gastric cancer.This article reviewed the importance and effectiveness of eradicating H.pylori in the progress of PLGC,in order to provide more references for clinical treatment.
作者
周举坤
张晓彤
孙振灿
王军
郑亚
王玉平
姬瑞
ZHOU Jukun;ZHANG Xiaotong;SUN Zhencan;WANG Jun;ZHENG Ya;WANG Yuping;JI Rui(The First Clinical Medical College of Lanzhou University,Lanzhou 730000;Department of Gastroenterology,the First Hospital of Lanzhou University;Digestive Endoscope Center,the First Hospital of Lanzhou University;The First Hospital of Lanzhou University,Gansu Province Clinical Research Center for Digestive Diseases,China)
出处
《胃肠病学和肝病学杂志》
CAS
2024年第5期594-598,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
甘肃省自然科学基金(22JR5RA906)
兰州市人才创新创业项目(2019-RC-33)
兰州大学第一医院院内基金(ldyyyn2021-95)。
关键词
幽门螺杆菌
胃癌前病变
化学预防
治疗
Helicobacter pylori
Precancerous lesions of gastric cancer
Chemoprevention
Treatment
