牛碱性成纤维细胞生长因子联合盐酸金霉素眼膏对正颌外科术后口角黏膜压力性损伤愈合的效果

Effect of bovine basic fibroblast growth factor combined with chlortetracycline hydrochloride eye ointment on wound healing of oral-mucosal pressure injury after orthognathic surgery

目的:研究外用牛碱性成纤维细胞生长因子联合盐酸金霉素眼膏用于正颌外科术后口角黏膜压力性损伤愈合的临床效果。方法:选取温州医科大学附属口腔医院2018年6月—2023年9月行正颌外科术后发生口角黏膜压力性损伤的患者为研究对象,根据用药方式不同,将患者分为盐酸金霉素眼膏组(30例)、外用牛碱性成纤维细胞生长因子组(30例)和外用牛碱性成纤维细胞生长因子联合盐酸金霉素眼膏组(简称联合组)(30例)。比较3组患者的疼痛程度、张口度、愈合时间及满意度。结果:用药第5天,3组VAS评分均较用药前显著下降(P<0.05),张口度均较用药前明显增大(P<0.05)。用药第5天,3组VAS评分和张口度差异有统计学意义(H=13.921,P=0.001;F=8.569,P<0.001),其中与金霉素眼膏和外用牛碱性成纤维细胞生长因子组相比,联合组的VAS评分最低、张口度最大(P<0.05)。3组用药前后VAS评分和张口度的差值差异有统计学意义(H=18.292,P<0.001;F=6.720,P=0.002),且联合组的差值均为最大。3组愈合时间和满意度差异均有统计学意义(F=9.510,P<0.001;χ^(2)=8.940,P=0.011),其中联合组的愈合时间最短、满意度最高(P<0.05)。结论:外用牛碱性成纤维细胞生长因子联合盐酸金霉素眼膏可促进正颌外科术后口角黏膜压力性损伤的愈合,减轻术后疼痛,增大张口度,缩短愈合时间,从而提高患者的满意度。

Objective:To explore the clinical effect of bovine basic fibroblast growth factor for external use combined with chlortetracycline hydrochloride eye ointment on wound healing of oral-mucosal pressure injury after orthognathic surgery.Methods:Patients with oral-mucosal pressure injury after orthognathic surgery in the Affiliated Hospital of Stomatology,Wenzhou Medical University from June 2018 to September 2023 were selected as subjects,who were divided into three groups according to the medication methods as the group of chlortetracycline hydrochloride eye ointment,the group of bovine basic fibroblast growth factor for external use and the group of bovine basic fibroblast growth factor for external use combined with chlortetracycline hydrochloride eye ointment(denoted as combination group),with 30 cases in each group.The pain degree,mouth opening,wound healing time and satisfaction degree were compared between the three groups.Results:After 5 days of medication,the visual analogue scale(VAS)score of the three groups were all significantly decreased(P<0.05)and the mouth opening of the three group were distinctly enlarged(P<0.05),compared with before medication.After 5 days of medication,the differences of VAS score and the mouth opening among the three group were statistically significant(H=13.921,P=0.001;F=8.569,P<0.001).The combination group had the lowest VAS score and the biggest mouth opening compared with the other two groups(P<0.05).There was statistical difference in the values of VAS score and the mouth opening before and after medication among the three group(H=18.292,P<0.001;F=6.720,P=0.002),and the difference value of the combination group was the biggest.The difference in the wound healing time and satisfaction degree for the three group were statistically significant(F=9.510,P<0.001;χ^(2)=8.940,P=0.011),in which the combination group had the shortest healing time and greatest satisfaction degree(P<0.05).Conclusion:The combination of bovine basic fibroblast growth factor for external use with chlortetracycline hydrochloride eye ointment can improve patients’satisfaction degree in that it promotes the wound healing of oral-mucosal pressure injury after orthognathic surgery,reduces postoperative pain and enlarges the mouth opening while shortens the wound healing time.