足细胞的发生发育与修复再生

Podocyte development and regenerative medicine of podocytopathy

足细胞由肾祖细胞逐步分化而来,通过形成足突和裂孔膜结构构成肾小球滤过膜的最后一层屏障。由足细胞损伤或功能障碍导致的肾小球疾病被称为足细胞病。阐明足细胞发育调控机制,有助于理解足细胞病的致病机制、开发针对性的靶向诊疗路径。该领域内的前沿热点之一,是采用类器官、诱导分化等技术构建足细胞病研究模型。本文对近年来足细胞发生与足细胞病相关的再生医学研究进展作一综述。

Podocytes are derived from nephron progenitor cells,and form the outer layer of glomerular filtration barrier by forming foot processes and slit diaphragm.Podocytopathies are caused by injury or dysfunction of podocytes.Explicating the regulation mechanism of podocyte genesis is helpful to understand the pathogenesis of podocytopathies,as well as to develop targeted clinical pathways.One of the frontiers in the field of podocytopathy research is to construct the disease model using organoids or induced differentiation techniques.This review focuses on the progress in podocyte genesis studies and the regenerative medicine researches about podocytopathy.