sKlotho保护尿毒症心肌病的机制

The protective effect of sKlotho on uremic cardiomyopathy

sKlotho是由“抗衰老”因子α-Klotho生成的可溶性蛋白,在体内发挥多效性作用。慢性肾脏病(CKD)是一种sKlotho缺乏性疾病,在CKD基础上发生的心脏重塑称为尿毒症心肌病(UC),以左心室肥厚和心肌纤维化为特征性表现,临床危害大,是CKD患者最主要的死亡原因。近年来研究发现,sKlotho可以保护心脏,通过靶向多种信号通路调控心肌肥厚、纤维化及心脏电生理。本文就sKlotho对UC的保护作用及其机制作一综述。

sKlotho,a soluble form of the anti-aging proteinα-Klotho,exerts multifaceted biological effects.Chronic kidney disease(CKD),marked by a deficiency in sKlotho,leads to the development of uremic cardiomyopathy(UC).UC,characterized by left ventricular hypertrophy and myocardial fibrosis,is a detrimental condition and a leading cause of mortality in patients undergoing dialysis.Emerging research has highlighted the cardioprotective potential of sKlotho,particularly in modulating signaling pathways associated with myocardial hypertrophy,fibrosis,and cardiac electrophysiology.This article comprehensively reviews the protective roles and mechanisms of sKlotho in the context of uremic cardiomyopathy,offering insights into novel therapeutic avenues.