小剂量艾司氯胺酮联合环泊酚在老年患者无痛胃肠镜检查中的临床应用评价

Clinical Evaluation of Low Dose Esketamine Combined with Cipofol in Painless Gastroenteroscopy in Elderly Patients

目的分析小剂量艾司氯胺酮联合环泊酚在老年患者无痛胃肠镜检查中的临床应用效果。方法方便选取2020年2月—2022年2月江苏省常州市武进人民医院麻醉科进行无痛胃肠镜检查的107例老年患者为研究对象,按随机数表法分为两组。对照组(50例)行环泊酚麻醉,观察组(57例)行小剂量艾司氯胺酮+环泊酚麻醉,对比两组的麻醉质量、平均动脉压(Mean Arterial Pressure,MAP)、心率(Heart Rate,HR)、不良反应发生率。结果观察组中,环泊酚用量、苏醒时间、定向力恢复时间均优于对照组,差异有统计学意义(P均<0.05)。观察组MAP和HR波动幅度小于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率(1.75%)明显低于对照组(16.00%),差异有统计学意义(χ^(2)=5.289,P=0.021)。结论老年无痛胃肠镜检查患者采用小剂量艾司氯胺酮+环泊酚静脉麻醉方式,便于麻醉剂量的降低,可缩短术后苏醒时间,不良反应较少。

Objective To analyze the clinical effect of low-dose esketamine combined with cyclopofol in painless gas⁃troenteroscopy in elderly patients.Methods From February 2020 to February 2022,107 elderly patients in the Depart⁃ment of Anesthesiology,Wujin People's Hospital,Changzhou,Jiangsu Province,for painless gastroenteroscopy were conveniently selected as the study objects.They were divided into two groups according to the method of random num⁃ber table.The patients in the control group(50 cases)were given cypofol anesthesia,and the observation group(57 cases)was given esketamine+cypofol anesthesia.The quality of anesthesia,mean arterial pressure(MAP),heart rate(HR)and adverse reactions were compared between the two groups.Results In the observation group,the dosage of cy⁃clopofol,recovery time and orientation recovery time were better than those in the control group,and the differences were statistically significant(all P<0.05).The magnitude of MAP and HR fluctuations in the observation group were smaller than those in the control group,and the differences were statistically significant(both P<0.05).The adverse re⁃actions of observation group(1.75%)was lower than that of control group(16.00%),and the difference was statistically significant(χ^(2)=5.289,P=0.021).Conclusion In elderly patients with painless gastroenteroscopy,intravenous anesthe⁃sia with small dose of esketamine+cyclopofol is conducive to reduce the anesthetic dose,shorten the postoperative re⁃covery time,and have less adverse reactions.