陀螺旋转式立体定向放射治疗局部晚期非小细胞肺癌的临床疗效

Clinical Efficacy of Gyro Rotary Stereotactic Radiotherapy for Locally Advanced Non-small Cell Lung Cancer

目的观察陀螺旋转式立体定向放射治疗(陀螺刀)治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效。方法以2021年1月-2023年3月上饶市立医院收治的60例局部晚期NSCLC患者为研究对象,依据随机数字表法分为对照组(30例)与观察组(30例)。对照组行常规放疗,观察组采用陀螺刀放疗,比较两组临床疗效、肿瘤标志物水平[鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)]、Karnofsky功能状态量表(KPS)评分、美国东部肿瘤协作组(ECOG)活动状态评分、急性放射性肺炎(ARP)发生情况、不良反应。结果观察组疾病控制率、客观缓解率高于对照组(P<0.05);两组治疗后SCC、CEA、NSE水平低于治疗前,且观察组SCC、CEA、NSE水平低于对照组(P<0.05);两组治疗后KPS评分高于治疗前,ECOG评分低于治疗前,且观察组KPS评分高于对照组,ECOG评分低于对照组(P<0.05);观察组ARP及不良反应发生率均小于对照组(P<0.05)。结论陀螺刀治疗局部晚期NSCLC效果肯定,可下调患者肿瘤标志物水平,改善其机体功能,降低ARP及不良反应的发生风险。

Objective To observe the clinical efficacy of gyro rotary stereotactic radiotherapy(gyro knife)in the treatment of locally advanced non-small cell lung cancer(NSCLC).Methods A total of 60 patients with locally advanced NSCLC admitted to Shangrao Municipal Hospital from January 2021 to March 2023 were divided into control group(30 patients)and observation group(30 patients)according to random number table method.The control group was treated with conventional radiotherapy,and the observation group was treated with gyro knife radiotherapy.The clinical efficacy,tumor marker levels[squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)],Karnofsky Performance Scale(KPS)score,Eastern Cooperative Oncology Group(ECOG)activity status score,acute radiation pneumonitis(ARP)occurrence,and adverse reactions were compared between the two groups.Results The disease control rate and objective remission rate of the observation group were higher than those of the control group(P<0.05).After treatment,the levels of SCC,CEA and NSE in the two groups were lower than those before treatment,and the levels of SCC,CEA and NSE in the observation group were lower than those in the control group(P<0.05).The KPS score of the two groups after treatment was higher than that before treatment,and the ECOG score was lower than that before treatment,whilethe KPS score of the observation group was higher than that of the control group,and the ECOG score was lower than that of the control group(P<0.05).The incidence of ARP and adverse reactions in the observation group were lower than those in the control group(P<0.05).Conclusion Gyro knife is effective in the treatment of locally advanced NSCLC,which can down-regulate the level of tumor markers,improve the body function,and reduce the risk of ARP and adverse reactions.