德谷胰岛素联合利拉鲁肽治疗难治性2型糖尿病的临床效果评价

Clinical Effect of Degu Insulin Combined with Liraglutide in Treatment of Refractory Type 2 Diabetes Mellitus

目的研究德谷胰岛素联合利拉鲁肽治疗难治性2型糖尿病的效果。方法选取2022年7月-2023年7月北京市第六医院收治的80例难治性2型糖尿病患者为研究对象,按随机数表法分为研究组、对照组,每组40例。对照组给予甘精胰岛素+门冬胰岛素联合治疗,研究组给予德谷胰岛素+利拉鲁肽联合治疗,分析两组治疗效果。结果治疗后,研究组糖化血红蛋白指标为(7.18±1.11)%、空腹血糖指标为(6.18±0.13)mmol/L、餐后2 h血糖指标为(7.35±1.15)mmol/L,均优于对照组的(8.28±1.01)%、(6.93±0.22)mmol/L、(8.02±1.58)mmol/L,差异有统计学意义(t=4.636、18.562、2.168,P均<0.05);治疗后,研究组胰岛功能优于对照组,差异有统计学意义(P<0.05);研究组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论运用德谷胰岛素+利拉鲁肽用药治疗难治性2型糖尿病可改善患者的胰岛功能、血糖指标,安全性高。

Objective To study the effect of degu insulin combined with liraglutide in the treatment of refractory type 2 diabetes mellitus.Methods A total of eighty patients with refractory type 2 diabetes admitted to Beijing Sixth Hospi-tal from July 2022 to July 2023 were selected as the study objects and divided into study group and control group by random number table method,with forty cases in each group.The control group was given the combination of insulin glargine and insulin aspartate,and the study group was given the combination of degu insulin and liraglutide.The therapeutic effect of two groups was analyzed.Results After treatment,the glycosylated hemoglobin index of the study group was(7.18±1.11)%,the fasting blood glucose index was(6.18±0.13)mmol/L,and the blood glucose index of 2 hours after meals was(7.35±1.15)mmol/L,which were better than(8.28±1.01)%,(6.93±0.22)mmol/L,(8.02±1.58)mmol/L of the control group,and the differences were statistically significant(t=4.636,18.562,2.168,all P<0.05).Af-ter treatment,islet function in the study group was better than that in the control group,and the difference was statisti-cally significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the con-trol group,and the difference was statistically significant(P<0.05).Conclusion The treatment of refractory type 2 dia-betes mellitus with deglu insulin and liraglutide can improve the islet function and blood glucose index of patients,and it is safe.