胰源性糖尿病的发病机制与诊治进展

Pathogenesis,diagnosis,and treatment of pancreatogenic diabetes

胰源性糖尿病是一种继发于胰腺外分泌疾病的糖尿病,2014年被美国糖尿病学会正式提出,其最常见的病因是慢性胰腺炎,其次是胰腺癌。目前该病的临床误诊率极高,且胰源性糖尿病患者相较于2型糖尿病患者有更高的死亡和再入院风险。因此,充分了解、并早期正确识别及诊断胰源型糖尿病,对降低该病的致残率与病死率具有重要意义。本文全面总结了继发于胰腺炎及胰腺癌的胰源性糖尿病的可能发病机制、诊治与管理等方面的研究进展。

Pancreatogenic diabetes is a type of diabetes mellitus secondary to exocrine pancreatic disease,and it was officially proposed by the American Diabetes Association in 2014,with chronic pancreatitis as the most common etiology,followed by pancreatic cancer.At present,the misdiagnosis rate of this disease is extremely high,and patients with pancreatogenic diabetes have a higher risk of death and readmission than patients with type 2 diabetes.Therefore,it is of great significance to fully understand,correctly identify,and diagnose pancreatogenic diabetes in the early state,so as to reduce the disability rate and mortality rate of this disease.This article reviews the advances in the possible pathogenesis,diagnosis,treatment,and management of pancreatic diabetes secondary to pancreatitis and pancreatic cancer.