mRNA纳米递送系统在CAR-T肿瘤免疫治疗中的应用

Application of mRNA nano-delivery system in CAR-T tumor immunotherapy

嵌合抗原受体T细胞(chimeric antigen receptor T cells, CAR-T)免疫疗法能够激活系统特异性免疫来实现抗肿瘤效应,近年来取得了令人振奋的进展。mRNA纳米递送系统以纳米颗粒包裹肿瘤免疫治疗相关抗原的mRNA,一方面能直接靶向于T细胞生成CAR-T细胞,直接作用于相应肿瘤细胞;另一方面可以通过靶向递送至抗原提呈细胞,辅助性增强CAR-T细胞功能,进一步诱导对肿瘤细胞产生特异性免疫反应,因而在CAR-T肿瘤免疫治疗中展现出巨大的潜力。本文就mRNA纳米递送系统的合成及其在CAR-T肿瘤免疫治疗中的研究和应用进行了综述。

Chimeric antigen receptor T cells(CAR-T)immunotherapy,which activates immunity specific to the system in order to achieve antitumor effects,has experienced exciting progress in recent years.mRNA nano-delivery systems,which encapsulate tumor immunotherapy-related antigen mRNA with nanoparticles,have shown great potential in CAR-T tumor immunotherapy.On one hand,these systems can directly target T cells to generate CAR-T cells that directly act upon the corresponding tumor cells.On the other hand,they can be delivered to antigen-presenting cells through targeting,thereby enhancing the function of CAR-T cells and further inducing specific immune responses against tumor cells.This review summarizes the synthesis of mRNA nano-delivery systems and their application in CAR-T tumor immunotherapy.