低分子肝素与脂肪乳联合抗复发性流产作用及对促炎介质、免疫功能的调节作用

Anti-Recurrent Abortion Effect of Low Molecular Weight Heparin Combined with Fat Milk and Its Modulating Effect on Proinflammatory Mediators and Immune Function

目的 探讨低分子肝素联合脂肪乳治疗复发性流产(RSA)的效果,分析其对妊娠结局、炎症介质、免疫功能的影响。方法 选取2021年2月至2022年3月驻马店市中医院收治的101例RSA患者为研究对象,随机分为单一组50例、联合组51例。两组接受常规基础治疗,在此基础上单一组接受脂肪乳治疗,联合组接受低分子肝素联合脂肪乳治疗,两组连续治疗至妊娠12周。对比两组临床疗效、妊娠结局、安全性。比较两组治疗前后T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、炎症介质[白介素-10(IL-10)、白介素-17(IL-17)、巨噬细胞炎性蛋白1α(MIP-1α)]水平。结果 联合组总有效率、妊娠成功率高于单一组(P<0.05),两组不良反应发生率差异无统计学意义(P>0.05)。联合组妊娠12周CD4^(+)、CD4^(+)/CD8^(+)低于单一组,CD8^(+)高于单一组(P<0.05),血清IL-10、MIP-1α水平高于单一组,IL-17水平低于单一组(P<0.05)。结论 低分子肝素联合脂肪乳治疗RSA的效果确切且具有一定安全性,可改善妊娠结局,减少炎症介质生成,调节机体免疫功能。

Objective To investigate the efficacy of low molecular weight heparin combined with fat milk in the treatment of recurrent abortion(RSA),and to analyze its effects on pregnancy outcomes,inflammatory mediators and immune function.Methods A total of 101 RSA patients from February 2021 to March 2022 were selected as the study objects,and randomly divided into single group(50 cases)and combined group(51 cases).Both groups received conventional basic treatment,and on this basis,the single group received fat emulsion treatment,while the combined group received low molecular weight heparin combined with fat emulsion treatment.Both groups were treated continuously until 12 weeks of pregnancy.The clinical efficacy,pregnancy outcomes and safety of the two groups were compared.The levels of T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),inflammatory mediators[interleukin-10(IL-10),interleukin-17(IL-17),macrophage inflammatory protein 1α(MIP-1α)]before and after treatment were compared between the two groups.Results The total effective rate and pregnancy success rate of the combined group were higher than those of the single group(P<0.05),while there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The CD4^(+)and CD4^(+)/CD8^(+)levels in the combined group were lower than those in the single group at 12 weeks of pregnancy,while the CD8^(+)level was higher than that in the single group(P<0.05).The serum IL-10 and MIP-1αlevels in the combined group were higher than those in the single group at 12 weeks of pregnancy,while the serum IL-17 level was lower than that in the single group(P<0.05).Conclusion The efficacy of low molecular weight heparin combined with fat emulsion in the treatment of RSA is precise and safe,which can improve pregnancy outcomes,reduce the production of inflammatory mediators,and regulate the immune function of the body.