血清ESM-1、HSP60水平与胃癌根治术患者预后的相关性

Correlation Between Serum ESM-1,HSP 60 Levels and Prognosis of Patients with Radical Gastrectomy for Gastric Cancer

目的:探讨血清内皮细胞特异性分子-1(ESM-1)、热休克蛋白60(HSP60)与胃癌根治术患者预后的关系。方法:选取2018年5月-2020年5月于信阳市中心医院确诊并行胃癌根治术治疗的136例胃癌患者作为研究对象。入院后次日,检测胃癌患者血清ESM-1、HSP60水平;术后对患者进行跟踪随访,随访时间截至2022年5月,评估患者预后情况,分析血清ESM-1、HSP60与胃癌根治术患者预后的相关性。结果:最终纳入130例患者进行研究;随访期间,130例胃癌患者中预后不良30例;预后不良组血清ESM-1、HSP60水平高于预后良好组,肿瘤分期为Ⅲ期、淋巴结转移占比高于预后良好组,差异有统计学意义(t=6.235、14.695;χ^(2)=2.742、10.566,P<0.05);经点二列相关性分析显示,血清ESM-1、HSP60与胃癌根治术患者预后呈正相关(r=0.632、0.675,P<0.05);血清ESM-1、HSP60二者联合预测的价值最佳(AUC=0.794)。结论:血清ESM-1、HSP-60水平与胃癌根治术患者预后有关,且血清ESM-1、HSP-60可作为预测患者预后的重要指标。

Objective:To investigate the relationship between serum endothelial cell specific molecule-1(ESM-1),heat shock protein 60(HSP 60)and prognosis of patients undergoing radical gastrectomy for gastric cancer.Methods:136 patients with gastric cancer diagnosed in Xinyang Central Hospital from May 2018 to May 2020 and treated with radical gastrectomy were included in this study.On the next day after admission,the serum ESM-1 and HSP 60 levels of patients with gastric cancer were detected.The patients were followed up after operation until May 2022.The prognosis of patients were evaluated,and the correlation between serum ESM-1,HSP 60 and prognosis of patients with radical gastrectomy were analyzed.Results:Among the 136 patients with gastric cancer included,30 had poor prognosis.Serum ESM-1,HSP 60,tumor stage and lymph node metastasis in patients with different prognosis were compared(t=6.235,14.695;χ^(2)=2.742,10.566;P<0.05).The point two column correlation analysis showed that serum ESM-1 and HSP 60 were positively correlated with the prognosis of patients undergoing radical gastrectomy(r=0.632,0.675;P<0.05).ROC curve of the subjects was drawn.The results showed that serum ESM-1 and HSP 60 had high predictive value for the prognosis of patients undergoing radical gastrectomy,and the predictive ability of the two was positively correlated(r=0.632,0.675;P<0.05).The combined predictive value of the two was the best(AUC=0.794).Conclusion:Serum ESM-1 and HSP-60 levels are related to the prognosis of patients undergoing radical gastrectomy,and serum ESM-1 and HSP-60 can be used as important indicators to predict the prognosis of patients.