基质金属蛋白酶在肺结核中的研究进展

Research progress of matrix metalloproteinase in pulmonary tuberculosis

肺结核是一种由结核分枝杆菌引起的慢性感染性疾病,其高患病率、高死亡率已对全球公共卫生构成严重威胁。基质金属蛋白酶(matrix metalloproteinase,MMP)是一类参与调节细胞外基质降解和重塑的蛋白水解酶。MMP在肺结核中高表达,其表达受基因、表观遗传修饰、细胞信号通路、免疫调节及细胞环境共同调控,MMP是肺结核治疗的潜在靶点。因此,该文总结了MMP在肺结核中的表达情况及相关作用机制,旨在为肺结核的诊治提供参考依据。

Tuberculosis is a chronic infectious diseases caused by Mycobacterium tuberculosis.Its high morbidity and mortality have posed a serious threat to global public health.Matrix metalloproteinase(MMP)is a proteolytic enzyme involved in regulating extracellular matrix degradation and remodeling.MMP is highly expressed in pulmonary tuberculosis,and its expression is regulated by genes,epigenetic modifications,cellular signaling pathways,immune regulation,and cellular environment.MMP is a potential target for the treatment of pulmonary tuberculosis.Therefore,this article summarizes the expression and related mechanisms of MMP in pulmonary tuberculosis,aiming to provide a reference for the diagnosis and treatment of pulmonary tuberculosis.