肿瘤靶向药物相关皮肤不良反应及发生机制

Cutaneous adverse reactions associated with targeted cancer therapy and its pathogenesis

近年来,肿瘤靶向药物快速发展,成为目前肿瘤治疗的重要选择之一。肿瘤靶向药物在发挥抗肿瘤作用的同时,可能损害正常组织功能,其中皮肤相关不良反应最为常见。部分皮肤不良反应严重影响患者的生活质量,导致其治疗依从性下降,最终影响患者的长期生存。因此,正确认识肿瘤靶向药物相关皮肤不良反应及发生机制,有助于指引未来基于机制的诊断与治疗,从而改善患者生活质量。

In recent years,targeted cancer therapy has developed rapidly and have become one of the most important choices for cancer treatment.While they exert anti-tumor effects,they may also damage the function of normal tissues,among which cutaneous adverse reactions are the most common.Some cutaneous adverse reactions severely affect patients’quality of life,lead to poor treatment compliance and ultimately affect the long-term survival.Therefore,a proper understanding of the cutaneous adverse reactions and its pathogenesis related to targeted cancer therapy can help guide future mechanism-based diagnosis and treatment,thus improve patients’quality of life.