穴位刺激治疗癌因性疲乏选穴规律数据挖掘

Data Mining of Acupoint Selection Rule for Treating Cancer-related Fatigue with Acupoint Stimulation

目的采用数据挖掘技术探究穴位刺激治疗癌因性疲乏的选穴配穴规律。方法检索中国知识资源总库(CNKI)、万方数据知识服务平台(Wanfang Data)、中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Embase建库至2023年10月13日收录的穴位刺激治疗癌因性疲乏的临床随机对照试验文献,采用Excel2021和R4.3.1对处方腧穴进行频次分析、关联规则分析和聚类分析。结果共纳入文献187篇,包含214条腧穴处方,涉及102个腧穴,使用总频次为1044。使用频次前3位腧穴为足三里、气海、关元,前3位经络为任脉、足阳明胃经和足太阴脾经;腧穴多分布在下肢部和胸腹部,交会穴为使用频次最高的特定穴,艾灸是最常用的干预措施。关联规则分析显示,足三里-气海-关元-三阴交为核心腧穴组合。对肺癌、乳腺癌、结直肠癌、妇科肿瘤和胃癌选穴分析显示,补虚要穴最常选用。聚类分析得到5组腧穴有效聚类群。结论穴位刺激治疗癌因性疲乏选穴以益气养血、扶正祛邪为主要原则,重视特定穴的使用,并根据脏腑经络辨证运用多种配穴方法以提高临床疗效。

Objective To analyze the acupoint selection rule for cancer-related fatigue with acupoint stimulation using data mining techniques.Methods Clinical randomized controlled trial research literature about treatment for cancer-related fatigue with acupoint stimulation was retrieved from CNKI,Wanfang Data,VIP,SinoMed,PubMed,Web of Science and Embase from establishment of the databases to October 13,2023.The frequency anlysis,association rule analysis and clustering analysis on acupoints were performed using Excel 2021 and R 4.3.1.Results Totally 187 articles were included,with 214 combinations of acupoints involving 102 acupoints,with a total frequency of 1044.The most frequently used acupoints were Zusanli(ST36),Qihai(CV6),and Guanyuan(CV4).The top three meridians used were the Conception Vessel,stomach meridian,and spleen meridian.The acupoints were mainly distributed in the lower limbs and thoracoabdominal,and the most commonly used specific acupoint was the crossing point.Moxibustion was the most commonly used intervention measure.Association rule analysis indicated that the core combination of acupoints in this study was Zusanli(ST36),Qihai(CV6),Guanyuan(CV4),and Sanyinjiao(SP6).Analysis of acupoint selection for cancer-related fatigue with different types of cancer demonstrated that acupoints with tonifying properties were most frequently chosen.Clustering analysis identified five effective combinations of acupoints.Conclusion The acupoint selection for treating cancer-related fatigue should focus on tonifying qi and nourishing blood,as well as supporting healthy qi to eliminate pathogenic factors.Special attention is given to the use of specific acupoints,and various acupoint combination methods are employed based on the differentiation of zang-fu organs and meridians to enhance clinical efficacy.