细胞自噬与代谢综合征的相关性及其中医药防治研究进展

Associations between autophagy and metabolic syndrome and advances in the prevention and treatment of metabolic syndrome with traditional Chinese medicine

代谢综合征(MetS)是一种临床特征为胰岛素抵抗、高血压、腹部肥胖、糖代谢受损和血脂异常等多种心血管危险因素集合的慢性非感染性疾病。目前MetS的发病率急剧上升,已成为一种全球性问题。系统性自噬缺陷会加重MetS。中医药可通过多途径、多靶点、多机制协同调控细胞自噬,因此如何基于自噬途径有效防治MetS成为了该领域的研究热点。该文概述了细胞自噬过程、机制,重点描述其与MetS主要病理机制的关系,并基于现代医学理论和中医认识方向,对中医药整方及其单味药有效成分通过细胞自噬途径对MetS的防治作用进行综述,为推进中西医结合防治MetS提供新的思路。

Metabolic syndrome(MetS)is a chronic non-infectious disease clinically characterized by a cluster of cardiovascular risk factors including insulin resistance,hypertension,abdominal obesity,impaired glucose metabolism,and dyslipidemia.The incidence of MetS is currently increasing dramatically and has become a global issue.Systemic defects in autophagy exacerbate MetS,while traditional Chinese medicine(TCM)can synergistically regulate cellular autophagy through multiple pathways,targets,and mechanisms.Thus,how to effectively prevent and treat MetS based on autophagy pathways has become a hot research topic in this field.This review outlines the process and mechanism of cellular autophagy,focusing on its relationship with the major pathological mechanisms of MetS,and summarizes the preventive and therapeutic effects of Chinese herbal formulas and their active ingredients on MetS through the cellular autophagy pathways based on the theories of modern medicine and the perspectives of TCM,thereby providing novel insights to promote the integration of TCM and Western medicine to prevent and treat MetS.