基于数据挖掘技术探讨龙运光教授辨治痹证的用药规律

Exploring the Medication Patterns of Professor LONG Yun-guang's Differentiation and Treatment of Bi Syndrome Based on Data Mining Technology

目的:基于中医传承计算平台(V3.5)挖掘龙运光教授治疗痹证的遣方用药特点及规律,为痹证的中医临床诊治提供参考。方法:筛选龙运光教授辨治痹证的相关医案并提取方药,以中医传承计算平台(V3.5)软件作为数据挖掘工具,对方药进行四气五味、归经功效、频次统计、组方规律、关联规则,以及聚类分析等数据挖掘。结果:共纳入龙运光教授辨治痹证方剂261个,涉及中药273味。四气以温性为主,其次为平、寒、凉、热。五味以甘味为主,其次为苦、辛、酸、咸。归经以肝经、脾经和肾经为主,常用核心药物组合16组,通过方剂聚类分析得到可能的新方组合5首。结论:从龙运光教授辨治痹证的相关医案中整理出方药,进行数据挖掘分析,总结出龙运光教授治疗痹证多从肝、脾、肾出发,药物以祛风湿类、活血化瘀类和补虚类为主,临床疗效较好,挖掘出的新方组合可为痹证的治疗提供一定参考。

Objective:Based on the Traditional Chinese Medicine Inheritance Computing Platform(V3.5),this study aims to explore the characteristics and patterns of Professor LONG Yun-guang's prescription and medication in the treatment of Bi syndrome,and provide reference for the clinical diagnosis and treatment.Methods:Relevant medical cases of Professor LONG Yun-guang in the diagnosis and treatment of Bi syndrome and prescriptions were selected.The Traditional Chinese Medicine Inheritance Calculation Platform(V3.5)was used to conduct data mining on the four qi and five flavors,meridian effects,frequency statistics,medication patterns,association rules,and cluster analysis of the prescriptions.Results:A total of 261 prescriptions were included,involving 273 Chinese medicines.The four qi are mainly characterized by warm,followed by neutral,cold,cool,and hot.The five flavors are mainly sweet,followed by bitter,acrid,sour,and salty.The meridian entry are mainly the liver meridian,the spleen meridian,and the kidney meridian,with 16 commonly used core drug combinations.Through formula clustering analysis,5 possible new formula combinations were obtained.Conclusion:Based on the above analysis,it is concluded that Professor LONG Yunguang's treatment of Bi syndrome mainly starts from the liver,spleen,and kidney,with drugs mainly focusing on dispelling wind and dampness,promoting blood circulation and removing stasis,and supplementing deficiency.The clinical efficacy is good,and the new combination of prescriptions mined can provide some reference for the treatment of Bi syndrome.