胶质母细胞瘤中血管生成拟态形成机制的研究进展

Research progress on the mechanism of vasculogenic mimicry formation in glioblastoma

血管生成拟态(VM)是一种类似血管的结构,存在于依赖血管的实体肿瘤中,是由高侵袭性肿瘤细胞通过自身变形和细胞外基质重塑形成的,是高侵袭性肿瘤进展的特殊供血来源。VM有两种类型:管状型和基质型,其中管状型是由肿瘤细胞构成的,而不是内皮细胞;基质型是由细胞外基质而不是细胞构成。VM在包括胶质母细胞瘤(glioblastoma,GBM)在内的多种人类恶性肿瘤中都有存在,与肿瘤的增殖、侵袭及复发都有很大的关系。本文就VM的概念、VM与GBM的关系、GBM中VM形成机制及针对VM治疗GBM的前景进行综述。

Vasculogenic mimicry(VM)is a vascular-like structure that exists in vascular-dependent solid tumors.It is formed by highly invasive tumor cells through self-deformation and extracellular matrix remodelingand is a special blood supply source involved in the progression of highly invasive tumors.There are two types of VM:tubular and matrix.The tubular form is made of tumor cells,not endothelial cells.The matrix form is made of extracellular matrix rather than cells.VM exists in many kinds of human malignant tumors,including glioblastoma(GBM),and is closely related to tumor proliferation,invasion and recurrence.This article reviews the concept of VM,the relationship between VM and GBM,the formation mechanism of VM in GBM and the prospect of VM therapy for GBM.