高产乙醇肺炎克雷伯菌的危害及感染应对策略

Harm and response strategies of high-alcohol-producing Klebsiella pneumoniae

高产乙醇肺炎克雷伯菌(HiAlc Kpn)能够在患者肠道内产生大量内源性乙醇,是非酒精性脂肪肝(NAFLD)的新病因,严重危害着人类健康。抗生素治疗是应对细菌感染的主要方式,然而肺炎克雷伯菌的耐药问题日益严重,且抗生素往往破坏人体肠道菌群的平衡。噬菌体疗法有望在不破坏健康肠道菌群的基础上,通过靶向杀伤HiAlc Kpn治疗NAFLD。同时,应积极寻找影响HiAlc Kpn产乙醇能力的目标靶点,为开发“抗毒力药物”提供理论基础。本文主要阐述HiAlc Kpn的危害性并提出治疗HiAlc Kpn感染的一些应对策略。

Objective High-alcohol-producing Klebsiella pneumoniae(HiAlc Kpn)can produce large amounts of endogenous alcohol in the intestines of patients,which is a new cause of nonalcoholic fatty liver disease(NAFLD)and seriously endangers human health.Antibiotic treatment is the main way to deal with bacterial infections,but the antibiotic resistance is becoming increasingly serious in K.pneumoniae,and antibiotics often disrupt the balance of human gut microbiota.Phage therapy is expected to treat NAFLD by targeted killing of HiAlc Kpn without destroying healthy intestinal microbiota.At the same time,we should actively search for targets that affect the alcohol-producing capacity of HiAlc Kpn,so as to provide theoretical basis for the development of anti-virulence drugs.This paper mainly describes the harmfulness of HiAlc Kpn and puts forward some strategies to treat HiAlc Kpn infection.