保妇康栓辅助治疗高危型HPV感染疗效及对HPV病毒载量和宫颈炎症的影响

Efficacy of Baofukang suppository for adjuvant treating patients with high-risk human papillomavirus infection and its influence on the human papillomavirus load and the cervicitis

目的:探究保妇康栓辅助重组人干扰素α-2b凝胶治疗高危型人乳头瘤病毒(HR-HPV)感染疗效及对HPV病毒载量和宫颈炎症的影响。方法:选取2022年1月-2023年2月本院收治的HR-HPV感染患者100例,随机分为对照组和观察组各50例。两组予以重组人干扰素α-2b凝胶治疗,观察组辅以保妇康栓治疗。比较两组临床疗效、阴道分泌物清洁度、Nugent评分、HPV病毒载量、宫颈炎症积分及血清炎症因子肿瘤坏死因子-α(TNF-α)、转化生长因子β1(TGF-β1)水平。结果:治疗后观察组临床总有效率(94.0%)高于对照组(74.0%),阴道分泌物清洁度(1.02±0.28)、Nugent评分(2.19±0.37分)及HR-HPV RLU/CO[4.37(0.08,2162.75)]均低于对照组(1.75±0.32、2.84±0.50分)[78.63(1.03,2633.41)],宫颈炎症积分(10.15±1.16分)及血清TNF-α(5.83±1.52 ng/L)、TGF-β1(16.37±2.41 ng/L)水平均低于对照组(17.43±1.55分、11.49±2.58 ng/L、21.56±2.67 ng/L)(均P<0.05)。两组不良反应总发生率(10.0%、20.0%)无差异(P>0.05)。结论:保妇康栓辅助重组人干扰素α-2b凝胶治疗HR-HPV感染疗效提高,可有效改善患者阴道清洁度,降低HPV病毒载量,缓解宫颈炎症,未增加不良反应。

Objective:To explore the efficacy of Baofukang suppository as adjuvant method of the recombinant human interferonα-2bgel for treating patients with high-risk human papillomavirus(HR-HPV)infection,and to study its effect on HPV viral load and the cervicitis of the patients.Methods:100patients with HR-HPV infection were selected and were randomly divided into two groups(50cases in each group)from January 2022to February 2023.The patients in the two groups were treated with the recombinant human interferonα-2bgel,and the patients in the observation group were given Baofukang suppository as adjuvant treatment additionally.The clinical efficacy,the vaginal secretion cleanliness degree,the Nugent score,the HPV load,the cervical inflammation score and the levels of serum inflammatory factors,such as tumor necrosis factor-α(TNF-α)and transforming growth factor-β1(TGF-β1),of the patients were compared between the two groups.Results:After treatment,the total clinical effective rate(94.0%)of the patients in the observation group was significantly higher than that(74.0%)of the patients in the control group.The vaginal secretion cleanliness degree(1.02±0.28),the Nugent score(2.19±0.37)and the RLU/CO of HR-HPV load[4.37(0.08,2162.75)]of the patients in the observation group were significantly lower than those(1.75±0.32,2.84±0.50)and 78.63(1.03,2633.41)of the patients in the control group.The cervical inflammation score(10.15±1.16 points),the levels of serum TNF-α(5.83±1.52ng/L)and TGF-β1(16.37±2.41ng/L)of the patients in the observation group were significantly lower than those(17.43±1.55points,11.49±2.58ng/L and 21.56±2.67ng/L)of the patients in the control group(all P<0.05).There was no significant difference in the total incidence of adverse reactions(10.0%vs.20.0%)of the patients between the two groups(P>0.05).Conclusion:Baofukang suppository combined with recombinant human interferonα-2bgel for treating the patients with HR-HPV infection can increase the effectiveness,which can effectively improve the vaginal cleanliness,reduce the HPV load and relieve the cervical inflammation of the patients,and without increase of the adverse reactions.