宫颈癌患者HPV感染因素分析及基因型分布

Analysis of the human papillomavirus(HPV)infection factors of patients with cervical cancer and the genotype distribution of HPV

目的:分析宫颈癌患者人乳头瘤病毒(HPV)感染情况及基因型分布。方法:选择2021年1月-2023年12月本院收治的351例宫颈癌患者临床资料,分析HPV感染情况及基因型分布情况,并用logistic回归分析筛选宫颈癌患者HPV感染的独立危险因素。结果:351例宫颈癌患者中336例HPV感染,HPV感染率95.7%。HPV感染组与非HPV感染组性伴侣数、宫颈炎病史有差异(P<0.05)。logistic回归分析显示,性伴侣数≥2个、有宫颈炎病史是宫颈癌患者HPV感染的独立危险因素。336例中,单一感染239例(71.1%),混合感染97例(28.9%),其中二重感染71例(21.1%)、多重感染26例(7.7%)。不同病理类型、临床分期、分化程度、淋巴结转移宫颈癌患者HPV单一感染率有差异,不同临床分期、分化程度、淋巴结转移宫颈癌患者的HPV混合感染率有差异,不同病理类型、临床分期宫颈癌患者的HPV总感染率有差异(均P<0.05)。239例HPV单一感染的宫颈癌患者中感染高危HPV亚型233例(97.5%),感染率前3位依次是HPV16(45.8%)、HPV18(6.8%)、HPV58(4.8%)。结论:本次调查的宫颈癌患者HPV感染率高,性伴侣数≥2个、有宫颈炎病史会增加患者HPV感染风险,且以单一感染为主,基因型前3位分别为高危HPV亚型16型、18型、58型。

Objective:To analyze the infection status of human papillomavirus(HPV)of patients with cervical cancer,and to study the genotype distribution of HPV.Methods:The clinical data of 351patients with cervical cancer who visited hospital from January 2021to December 2023were selected in this study.The HPV infection status and the genotype distribution of HPV of the patients were analyzed.Logistic regression analysis was applied to screen the independent risk factors of HPV infection of the patients with cervical cancer.Results:Among 351patients with cervical cancer,there were 336(95.7%)cases with HPV infection.There were significant differences in the number of sexual partners and the history of cervicitis between the patients with and without HPV infection(P<0.05).Logistic regression analysis showed that the number of sexual partners≥2people and the history of cervicitis of the patients with cervical cancer were the independent risk factors of their HPV infection.Among 336patients with HPV infection,there 239(71.1%)cases with the single HPV infection and 97cases(28.9%)cases with the mixed infection of HPV,including 71(21.1%)cases with double HPV infection and 26(7.7%)cases with multiple HPV infection.There was significant difference in the single HPV infection rate among the patients with different pathological types of the cervical cancer,among the patients with different clinical stages of the cervical cancer,among the patients with different differentiation degrees of the cervical cancer cell and among the patients with different lymph node metastasis situations.There was significant difference in the mixed HPV infection rate among the patients with different clinical stages of the cervical cancer,among the patients with different differentiation degrees of the cervical cancer cell and among the patients with different lymph node metastasis situations.There was significant difference in the total HPV infection rate among the patients with different pathological types of the cervical cancer and among the patients with different clinical stages of the cervical cancer(all P<0.05).Among 239cervical cancer patients with single HPV infection,there were 233(97.5%)cases with high-risk HPV subtypes infection,and the top three infection rates of the HPV subtypes were HPV16(45.8%),HPV18(6.8%)and HPV58(4.8%).Conclusion:This study shows that the patients with cervical cancer have the higher HPV infection rate.The number of sexual partners≥2people and the history of cervicitis of the patients with cervical cancer can increase their HPV infection risk.The HPV infection of the patients with cervical cancer is mainly the single HPV infection,the top three genotypes of HPV subtypes infection are HPV 16,HPV 18,and HPV 58.