门冬胰岛素治疗2型糖尿病患者对不良反应发生率的影响

Effect of Insulin Aspart on Incidence of Adverse Reactions of Patients with Type 2 Diabetes

目的探究门冬胰岛素治疗2型糖尿病患者对不良反应发生率的影响。方法选取2020年1月—2023年1月江阴市第三人民医院收治的60例2型糖尿病患者作为研究对象,并随机分为对照组和观察组,每组30例。其中,对照组采用二甲双胍治疗,观察组采用门冬胰岛素治疗,比较两组的血糖水平(FBG、2hPG、HbAlc)、不良反应发生率(胃肠道反应、乳酸性酸中毒、局部皮肤过敏)及治疗3个月后病情控制有效率(显效、有效、无效)。结果治疗前,两组血糖水平差异不显著(P>0.05);治疗后,观察组空腹血糖、餐后2h血糖及糖化血红蛋白均低于对照组(P<0.05)。观察组的不良反应总发生率显著低于对照组(P<0.05)。治疗3个月后,观察组的病情控制显效高于对照组,无效低于对照组,总有效率显著高于对照组(P<0.05)。结论门冬胰岛素可以显著降低2型糖尿病患者的不良反应发生率。

Objective To explore effect of insulin aspart on incidence of adverse reactions of patients with type 2 diabetes.Methods The paper chose 60 patients with type 2 diabetes in Jiangyin City the Third People's Hospital from January 2020 to January 2023 as research objects,and divided them into groups randomly,30 cases in control group,and 30 cases in observation group.Control group was treated with metformin,and observation group with insulin aspart.Blood glucose level(FBG,2hPG,HbAlc),incidence of adverse reactions(gastrointestinal reactions,lactic acidosis,local skin allergy),and effective rate of disease control after three months of treatment(significant,effective,ineffective)was compared between two groups.Results Before treatment,there was no significant difference in blood glucose levels between two groups(P>0.05).After treatment,fasting blood glucose,2-hour postprandial blood glucose,and glycated hemoglobin in observation group was lower than control group(P<0.05).Total incidence of adverse reactions in observation group was significantly lower than control group(P<0.05).After 3 months of treatment,disease control in observation group was significant better than control group,while ineffective rate was lower than control group.Total effective rate in observation group was significantly higher than control group(P<0.05).Conclusion Insulin aspart can reduce incidence of adverse reactions of patients with type 2 diabetes significantly.