Novel MEI1 compound heterozygous mutation in a sporadic family associated with spermatogenetic failure

Dear Editor,Male infertility is a complex and multifactorial health problem with highly heterogeneous phenotypes,ranging from reduced sperm production to the complete absence of sperm in testis,and genetic factors play an important role in this problem.1 Patients with azoospermia have the highest risk of carrying genetic abnormalities,and this risk gradually decreases as sperm count increases.1 Due to the high throughput and low cost of next-generation sequencing(NGS)technology,many centers have used NGS to identify genetic defects associated with abnormal spermatogenesis.