增强性体外反搏联合运动训练对老年慢性肾脏病患者衰弱和运动能力的影响:一项前瞻性研究

Effects of enhanced external counterplusation combined with exercise training on frailty and exercise capacity in elderly pa⁃tients with chronic kidney disease:a prospective study

目的本研究旨在探索增强型体外反搏联合运动训练对老年慢性肾脏病患者衰弱程度和运动能力的影响。方法本研究为前瞻性试验,共招募112例年龄60~80岁的慢性肾脏病患者。采用随机对照研究将观察对象分为4组,包括常规组27例、运动组32例、增强性体外反搏组25例和联合组28例。研究期限为3个月,主要评估指标为衰弱评分和运动能力。结果治疗后,增强性体外反搏组、联合组在疲劳分项变化明显低于治疗前,差异有统计学意义(P<0.01);联合组在体力活动下降分项有改善,较治疗前差异有统计学意义(P<0.05);联合组衰弱总分显著降低,差异有统计学意义(P<0.05);运动组、联合组30s⁃STS评分比治疗前显著升高,差异有统计学意义(P<0.05)。结论运动可以提高老年慢性肾脏病患者的活动能力,增强性体外反搏能显著缓解疲劳,增强性体外反搏联合运动训练对缓解老年慢性肾脏病患者衰弱症状,改善运动能力有显著效果。

Objective The aim of this study was to explore the effects of enhanced external counterplusation(EECP)combined with exercise training on the frailty and exercise ability of elderly patients with chronic kidney disease(CKD).Methods A total of 112 patients with CKD aged between 60 and 80 years were enrolled in this prospective trial.The randomized controlled study divided the subjects into four groups,including conventional treatment group 27cases,exercise training group 32cases,EECP treatment group 25cases and EECP combined exercise training group 28cases.The duration of the study was 3 months,and the main measures were frailty score and exercise ability.Results After treatment,the fatigue changes in EECP group and combined group were significantly lower than before treatment,and the difference was statistically significant(P<0.01).The physical activity decline in the combined group was significantly improved compared with that before treatment(P<0.05).The total score of frailty in combination group was significantly decreased,with statistical significance(P<0.05).The 30s⁃STS scores of exercise group and combination group were sig⁃nificantly higher than those before treatment,and the difference was statistically significant(P<0.05).Conclusion Exercise can im⁃prove the activity ability of elderly patients with CKD,EECP can significantly relieve fatigue,and EECP combined with exercise training has a significant effect on alleviating the debilitating symptoms and improving the exercise ability of elderly patients with CKD.