老年2型糖尿病患者糖尿病视网膜病变与血清纤维蛋白原、血清淀粉样蛋白A的相关性研究

Correlation between serum FIB,SAA and diabetes retinopathy in elderly patients with type 2 diabetes

目的研究老年2型糖尿病患者糖尿病视网膜病变与血清纤维蛋白原(FIB)、血清淀粉样蛋白A(SAA)的相关性。方法以2020年1月至2023年6月在我院内分泌科就诊的95例老年2型糖尿病患者作为研究对象,根据其是否发生视网膜病变分为对照组与病变组,采集两组研究对象的一般资料、常规实验室生化指标、FIB、SAA,并对上述指标与视网膜病变的相关性进行分析。结果与对照组相比,病变组的SBP、DBP、FPG、FINS、2hPG、2hINS、HbA1c、TG、TC、HDL⁃C、LDL⁃C、CRP表达水平高,其中HbA1c、LDL⁃C水平差异有统计学意义(P<0.05);病变组血清的FIB、SAA水平高。多因素Logistic回归分析结果显示,血清HbA1c、LDL⁃C、FIB、SAA是患者合并视网膜病变的独立影响因素;相关性分析得出血清HbA1c、LDL⁃C、FIB、SAA与发生糖尿病视网膜病变呈正相关(相关系数rp>0.7,P<0.05)。结论血清HbA1c、LDL⁃C、FIB及SAA与老年2型糖尿病患者糖尿病视网膜病变呈正相关,是视网膜病变发生的危险因素。

Objective To study the correlation between serum FIB and SAA and diabetes retinopathy in elderly patients with type 2 diabete.Methods Prospective analysis of 95 patients with type 2 diabetes who visited the endocrinology department of our hospital from January 2020 to June 2023 as research subjects,according to whether they had retinal lesions,they were divided into the control group and the lesion group,and the general data of the two groups of research subjects,conventional laboratory biochemical indicators FIB,SAA,and the correlation between the above indicators and retinal lesions was analyzed.Results Compared with the control group,the expression levels of SBP,DBP,FPG,FINS,2hPG,2hINS,HbA1c,TG,TC,HDL⁃C,LDL⁃C and CRP in the diseased group were higher,of which the differences in HbA1c and LDL⁃C were statistically significant(P<0.05).The serum of the diseased group had high levels of FIB and SAA(P<0.05).The results of multi⁃factor Logical regression analysis showed that the serum HbA1c,LDL⁃C,FIB and SAA were independent influencing factors for patients with combined retinitis pigmentosa;correlation analy⁃sis shows that serum HbA1c,LDL⁃C,FIB and SAA were positively correlated with the occurrence of retinitis pigmentosa in T2DM(correlation coefficient rp>0.7,P<0.05).Conclusion Serum HbA1c,LDL⁃C,FIB and SAA were positively correlated with reti⁃nal disease in elderly patients with diabetes and risk factors for retinal disease.