摘要
目的总结罗沙司他药物使用过程中的常见不良反应,提高临床医生对其不良反应的认知。方法对1例慢性肾脏病(chronic kidney disease,CKD)血液透析患者口服罗沙司他胶囊后出现的药物相关不良反应进行回顾性分析,并进行文献复习。结果该患者因肾性贫血口服罗沙司他胶囊后出现严重腹泻、恶心、呕吐症状就诊,完善相关化验检查提示合并肝功能受损,入院后给予连续性床旁血液滤过、保护肝功能、抗感染、补液等治疗,患者症状及化验结果逐渐改善,最终病情好转出院。结论罗沙司他作为治疗肾性贫血的新型口服药物,其药物安全性仍需要进行进一步的研究,临床医生在使用该药物过程中对其不良反应的认知仍需要进一步加强。
Objective To investigate the safety of Roxadustat on anemia to improve understanding of its adverse drug reactions.Methods Clinical data of a patient with dialysis-dependent chronic kidney disease(DD-CKD)and renal anemia who were treated with Roxadustat and experienced treatment-emergent adverse events was retrospectively analyzed,and related literature was reviewed.Results After treated with Roxadustat,the patient has severe symptoms of diarrhea,nausea,and vomiting,and laboratory tests indicated concurrent liver failure.After admission,continuous renal replacement therapy(CRRT),protecting liver function,anti-infection,and other treatments were given to the patient.The patient's symptoms and laboratory results gradually improved,and ultimately the patient was discharged from the hospital.Conclusion As a novel oral medication for the renal anemia,further researches are needed on the adverse drug reactions with Roxadustat,we need to strengthen the understanding of its adverse drug reactions during the use of Roxadustat.
作者
杨晓丽
王磊
范勇霞
平金超
YANG Xiaoli;WANG Lei;FAN Yongxia;PING Jinchao(Department of Nephrology,Beijing Changping Hospital,Beijing 102200,China;Deparment of Hemodialysis Center,Beijing Changping Hospital,Beijing 102200,China)
出处
《中国老年保健医学》
2024年第2期139-142,共4页
Chinese Journal of Geriatric Care
关键词
低氧诱导因子脯氨酰羟化酶抑制剂
罗沙司他
不良反应
血液透析
肾性贫血
hypoxia-inducible factor prolyl hydroxylase inhibitor(HIF-PHI)
Roxadustat
renal anemia
adverse drug reactions
renal dialysis