无创高频震荡通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征的疗效观察

Non invasive high-frequency oscillatory ventilation combined with pulmonary surfactant therapy observation on therapeutic effect of neonatal respiratory distress syndrome

目的研究新生儿呼吸窘迫综合征(NRDS)患儿经无创高频震荡通气(nHFV)联合猪肺表面活性物质(PS)治疗的临床疗效观察。方法选取2020年1月—2023年1月周口市中心医院收治的NRDS患儿120例,按治疗方法的不同分为观察组60例,对照组60例。所有观察组患儿应用nHFV联合PS治疗,对照组的新生儿呼吸窘迫患儿采用经鼻持续正压通气(nCPAP)联合PS治疗。对两组患儿的临床治疗有效率、血气指标(PH、动脉血氧分压PO_(2)、二氧化碳分压PCO_(2)、吸入氧浓度FiO_(2)、氧合指数OI)和并发症发生率进行对比。结果观察组60例新生儿呼吸窘迫患儿总有效率明显高于对照组(P<0.05)。观察组60例患儿血气指标提示PO_(2)高于对照组,PO_(2)、FiO_(2)、OI均低于对照组,两组差异有统计学意义(P<0.05)。两组患儿肺炎、支气管肺发育不良、气漏、坏死性小肠结肠炎、颅内出血、肺出血等并发症发生率有明显差异(P<0.05)。结论NRDS患儿通过nHFV联合PS治疗临床疗效显著,可有效提高NRDS治疗效果,可改善患儿动脉血气指标及患儿缺氧症状,并发症发生率降低,有效缩短住院时间及离氧时间,节约住院花费。

Objective To investigate the clinical efficacy of non-invasive high-frequency oscillatory ventilation(nHFV)combined with porcine pulmonary surfactant(PS)treatment in children with neonatal respiratory distress syndrome.Methods Totally 120 samples of NRDS patients admitted to Zhoukou Central Hospital from January 2020 to January 2023 were selected and randomly divided into an observation group of 60 cases and a control group of 60 cases according to different treatment methods.All observation group children were treated with nHFV combined with PS,while the control group with respiratory distress were treated with nasal continuous positive pressure ventilation(nCPAP)combined with PS.Compare the clinical treatment efficacy,blood gas indicators(pH,arterial oxygen partial pressure PO_(2),PO_(2),FiO_(2),OI),and incidence of complications between two groups of children.Results The total effective rate of 60 newborns with respiratory distress in the observation group was significantly higher than that of the control group(78%<93%).Through treatment,the blood gas indicators of 60 children in the observation group showed that PO_(2) was higher than the control group,while PO_(2),FiO_(2),and OI were lower than the control group.The difference between the two groups was statistically significant(P<0.05).There was a significant difference in the incidence of complications such as pneumonia,BPD,air leakage,NEC,intracranial hemorrhage,and pulmonary hemorrhage between the two groups of children(P<0.05).Conclusion The clinical efficacy of nHFV combined with PS treatment in children with NRDS is significant,which can effectively improve the treatment effect of NRDS,improve arterial blood gas indicators and hypoxia symptoms in children,reduce the incidence of complications,effectively shorten oxygen use time and hospitalization time,and save hospitalization costs.