羟考酮联合七氟烷在妇科腹腔镜手术中的应用效果

Effect of oxycodone combined with sevoflurane in gynecological laparoscopic surgery

目的观察羟考酮联合七氟烷在妇科腹腔镜手术中的应用效果。方法将2019年1月至2022年12月期间在浙江省台州市第一人民医院接受妇科腹腔镜全身麻醉手术治疗的90例患者作为研究对象,按治疗方法分为观察组和对照组,每组各45例。2组均给予七氟烷吸入麻醉,观察组手术结束时给予羟考酮,对照组手术结束时给予右美托咪定。对比2组患者术后并发症,不同时间的视觉模拟评分法(VAS)、拔管后Ramsay镇静评分、Richmond躁动-镇静评分(RASS评分)。结果观察组术后1 h、术后6 h、术后12 h、术后24 h VAS评分均低于对照组(P<0.05);观察组拔出导管5 min、10 min、20 min、60 min后Ramsay镇静评分高于对照组(P<0.05);观察组拔出导管后5 min、10 min的RASS评分均低于对照组(P<0.05);2组不良反应发生率相比,差异无统计学意义(P>0.05)。结论羟考酮联合七氟烷能够明显改善妇科患者腹腔镜手术后镇痛、镇静评分,降低RASS评分。

Objective To assess the effect of oxycodone combined with sevoflurane during gynecological laparoscopic surgery.Methods Between January 2019 to December 2022,a total of 90 patients who underwent gynecological laparoscopic surgery under general anesthesia were selected as study subjects in First People′s Hospital of Taizhou.These patients were assigned to an observation group and a control group according to treat-ment,with 45 patients in each group.Both groups received sevoflurane inhalation anesthesia.Additionally,the ob-servation group was administered oxycodone at the end of surgery,while the control group received dexmedetomi-dine.Postopera-tive outcomes were evaluated using the Visual Analogue Scale(VAS)for pain,Ramsay Sedation Score for sedation levels post-extubation,and the Richmond Agitation Sedation Scale(RASS)at various time points.These metrics were compared between the two groups to assess any differences in postoperative complica-tions.Results The VAS scores of the observation group were significantly lower than those of the control group at 1 h,6 h,12 h,and 24 h postoperatively(P<0.05).Furthermore,the Ramsay Sedation Scores in the observation group were higher compared to the control group at 5 min,10 min,20 min,and 60 min post-extubation(P<0.05).Additionally,the RASS scores of the observation group were lower than those of the control group at 5 min and 10 min after catheter removal(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of oxycodone with sevoflurane effectively enhances analgesia and sedation scores among gynecological patients following laparoscopic surgery,while also reducing RASS scores.