摘要
Ultrasound(US)is a kind of acoustic wave with frequency higher than 20 kHz.Learning from the echo detection ability of bats and dolphins,scientists applied US for clinical imaging by sending out US waves and detecting echoes with shifted intensities and frequencies from human tissue.US has long played a critical role in noninvasive,real-time,low-cost and portable diagnostic imaging.With the in-depth study of US in multidisciplinary fields,US and US-responsive materials have shown practical value in not only disease diagnosis,but also disease treatment.In this review,we introduce the recently proposed and representative US-responsive materials for biomedical applications,including diagnostic and therapeutic applications.We focused on US-mediated physicochemical therapies,such as sonodynamic therapy,high-intensity focused US ablation,sonothermal therapy,thrombolysis,etc,and US-controlled delivery of chemotherapeutics,gases,genes,proteins and bacteria.We conclude with the current challenges facing the clinical translation of smart US-responsive materials and prospects for the future development of US medicine.
基金
the National Key Research and Development Program of China(Grant No.2020YFA0908200)
the National Natural Science Foundation of China(Grant Nos.T2225003,52073060 and 61927805)
the Nanjing Medical Science and Technique Development Foundation(Grant No.ZKX21019)
the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021B1515120054)
the Shenzhen Fundamental Research Program(Grant Nos.JCYJ20190813152616459 and JCYJ20210324133214038).
