RNA的N^(6)-甲基腺嘌呤甲基化在肿瘤放疗中的作用研究进展

Research progress in the mechanism of m6A RNA methylation modification in radiotherapy for malignant tumors

随着表观遗传转录组学的深入探究,越来越多的研究发现N^(6)-甲基腺嘌呤(m^(6)A)甲基化作为真核生物mRNA上含量最高的化学修饰,在恶性肿瘤的发生和发展中发挥了重要作用。m^(6)A RNA甲基化修饰在肿瘤放射治疗中的作用研究逐渐成为热点,其可能通过调节辐射诱导的DNA损伤修复、参与肿瘤干细胞的辐射抗性、调控肿瘤放射敏感性、影响放疗相关不良反应及优化放疗联合其他治疗的协同效应等途径,干预肿瘤放疗的疗效及预后。本文就有关RNA的m^(6)A甲基化修饰在肿瘤放射治疗中的调控机制研究进展进行综述,旨在为探索肿瘤放射治疗研究中的潜在靶点、探寻发挥增效减毒作用的关键环节提供新的思路。

Many epigenetic transcriptome studies have found that N6 methyladenine(m6A)methylation,as the most abundant chemical modification on eukaryotic mRNA,plays an important role in the occurrence and development of malignant tumors.It might affect the effectiveness and prognosis of tumor radiotherapy by regulating radiation induced DNA damage,participating in radiation resistance of tumor stem cells,controlling tumor radiosensitivity,intervening in radiation related adverse reactions,and optimizing the synergistic effect of radiotherapy combined with other treatments.In this article,the research progress in the epigenetic mechanism of m6A RNA methylation modification in tumor radiotherapy was reviewed,aiming to provide ideas for exploring potential new targets for tumor radiotherapy and searching for radiation sensitization and toxicity reduction biomarkers.