阿立哌唑与硫必利对抽动障碍患儿疗效及T淋巴细胞亚群、神经递质的影响

Effects of aripiprazole and tiapride in children with Tic disorder and their influence on the T lymphocyte subsets and neurotransmitterssubsets and neurotransmitters

目的对比阿立哌唑与硫必利治疗抽动障碍患儿的疗效及对T淋巴细胞亚群、神经递质的影响。方法选我院2020年9月~2022年9月收入的抽动障碍患儿76例为研究对象,按照随机数表法将其分为阿立哌唑组(38例)和硫必利组(38例),分别接受阿立哌唑片治疗和盐酸硫必利片治疗。比较两组患儿临床治疗效果、T淋巴细胞亚群值、神经递质水平变化情况,记录两组患儿治疗不良反应发生概率。结果与硫必利组相比,阿立哌唑组总有效率更高(P<0.05)。治疗后两组CD3^(+)、CD3^(+)CD4^(+)、CD4^(+)/CD8^(+)值均上升,且阿立哌唑组上升更明显(P<0.05)。治疗后两组多巴胺(DA)、去甲肾上腺素(NE)、5羟色胺(5-HT)水平均下降,且阿立哌唑组下降更明显(P<0.05)。阿立哌唑组不良反应发生率为5.3%(2/38),硫必利组不良反应发生率为21.1%(8/38),阿立哌唑组不良反应总发生率更低(P<0.05)。结论阿立哌唑与硫必利在治疗抽动障碍方面均有较好疗效,但阿立哌唑对T淋巴细胞亚群、神经递质改善更好,且安全性更高。

Objective To compare and analyze the effects of aripiprazole and tiapride on the efficacy,T lymphocyte subsets and neurotransmitters of children with tic disorder.Methods 76 children with tic disorder who were admitted to our hospital from September 2020 to September 2022 were divided into aripiprazole group(38 cases)and tiapride group(38 cases)according to the random number table method.The aripiprazole group received aripiprazole tablets and the tiapride group received tiapride hydrochloride tablets.The clinical curative effect,T-lymphocyte subgroup value,neurotransmitter level and the probability of adverse reactions were compared between the two groups.Results Compared with Tiapride group,the total effective rate of aripiprazole group was higher(P<0.05).After treatment,the values of CD3+,CD3+CD4+,CD4+/CD8+increased in both groups,and the increase was more significant in aripiprazole group(P<0.05).After treatment,the levels of dopamine(DA),norepinephrine(NE)and 5-hydroxytryptamine(5-HT)in both groups decreased,and the decrease in aripiprazole group was more significant(P<0.05).The incidence of adverse reactions was 5.3%(2/38)in aripiprazole group,21.1%(8/38)in tiapride group,and lower in aripiprazole group(P<0.05).Conclusion Both aripiprazole and tiapride have good efficacy in the treatment of tic disorders,but aripiprazole has better improvement in T-lymphocyte subsets and neurotransmiters,and higher safety.