米那普仑联合认知行为疗法对轻型颅脑外伤后抑郁患者血清5-HT、BDNF及睡眠质量的影响

Effects of Minapram combined with cognitive behavioral therapy on serum 5-HT,BDNF and sleep quality in patients with depression after mild craniocerebral trauma

目的探讨米那普仑联合认知行为疗法对轻型颅脑外伤后抑郁患者血清5-羟色胺(5-hydroxytryptamine,5-HT)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)及睡眠质量的影响。方法选取2020年6月~2023年6月我院收治的100例轻型颅脑外伤后抑郁患者,随机分为观察组与对照组各50例。对照组给予认知行为疗法,观察组联用米那普仑,两组疗程均为2个月。评估两组临床疗效;记录治疗前及治疗2个月后两组相关抑郁量表评分、睡眠质量量表评分及血清5-HT、BDNF水平;记录两组不良反应。结果观察组总有效率更高(P<0.05)。治疗后,相较于对照组,观察组相关抑郁量表及睡眠质量量表评分更低(P<0.05)。治疗后,相较于对照组,观察组5-HT、BDNF更高(P<0.05)。两组不良反应发生概率比较无差异(P>0.05)。结论米那普仑联合认知行为疗法能够显著减少轻型颅脑外伤后抑郁患者抑郁情绪,改善其睡眠质量,且具有较高安全性。

Objective To investigate the effect of milnapran combined with cognitive behavioral therapy on serum 5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF)and sleep quality in patients with depression after mild traumatic brain injury.Methods A total of 100 patients with depression after mild craniocerebral trauma admitted to our hospital from June 2020 to June 2023 were randomly divided into observation group and control group with 50 cases in each group.The control group received cognitive behavioral therapy,and the observation group received minapram.The treatment course of both groups was 2 months.Evaluate the clinical efficacy of the two groups.Before treatment and 2 months after treatment,the scores of related depression scale,sleep quality scale and serum 5-HT and BDNF were recorded;the adverse reactions of the two groups were recorded.Results The total effective rate was higher in the observation group(P<0.05).Aftertreatment,compared with the control group,the scores of related depression scale and sleep quality scale in the observation group were lower(P<0.05).Afer treatment,compared with the control group,the levels of 5-HT and BDNF in the observation group were higher(P<0.05).There was no difference in the probability of adverse reactions between the two groups(P>0.05).Conclusion Minapram combined with cognitive behavioral therapy can significantly reduce depressive mood and improve sleep quality in patients with mild traumatic depression,and has a high safety.