斑马鱼在肝病模型中的研究进展

Advances in Study of Zebrafish in Models of Liver Disease

肝脏是人体进行能量代谢的主要场所。肝病是严重影响人们生活质量的临床疾病之一,多种因素导致肝脏功能及结构异常。目前关于肝病模型的基础研究已取得一定进展,多种肝病模型用于肝病机制的研究,可有效复制肝病的临床特征及病变过程。采用大鼠、小鼠复制肝病模型均存在弊端,基础实验研究中采用斑马鱼复制肝病模型具有自身优势,在肝病治疗药物筛查中具有重要意义。全面了解斑马鱼在肝病模型中的作用,可以为相关疾病的治疗提供新思路。

The liver is the main site of energy metabolism in the body.Liver disease is one of the clinical diseases that seriously affect people's quality of life,and a variety of factors lead to functional and structural abnormalities of the liver.At present,some progress has been made in basic research on liver disease models,and a variety of the models have been used to study the disease mechanism,which can effectively reproduce the clinical features and pathological processes.The use of rats and mice to reproduce liver disease models has disadvantages,while the use of zebrafish to reproduce liver disease models in basic experimental research has its own advantages and is of great significance in the screening of the therapeutic drugs.A comprehensive understanding of the role of zebrafish in liver disease modeling may provide new ideas for the treatment of related diseases.