瑞舒伐他汀联合常规疗法治疗冠心病合并慢性心力衰竭的临床效果分析

Clinical Effect Analysis of Rosuvastatin Combined with Conventional Therapy in Treatment of Coronary Heart Disease Complicated with Chronic Heart Failure

目的:探讨瑞舒伐他汀联合常规疗法治疗冠心病合并慢性心力衰竭的临床效果。方法:选取2021年7月—2023年2月东营市东营区辛店街道社区卫生服务中心收治的94例冠心病合并慢性心力衰竭患者作为研究对象,随机分为试验组与常规组,各47例。常规组采用常规疗法治疗,试验组在常规组基础上应用瑞舒伐他汀治疗。比较两组治疗效果。结果:试验组治疗总有效率高于常规组,差异有统计学意义(P<0.001)。治疗前,两组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)比较,差异无统计学意义(P>0.05);治疗后,两组LVEF高于治疗前,且试验组高于常规组,两组LVEDD、LVESD小于治疗前,且试验组小于常规组,差异有统计学意义(P<0.05)。治疗前,两组高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组hs-CRP、IL-6、TNF-α水平低于治疗前,且试验组低于常规组,差异有统计学意义(P<0.05)。结论:瑞舒伐他汀联合常规疗法治疗冠心病合并慢性心力衰竭的临床效果显著,能够改善心功能,减轻炎性反应。

Objective:To study the clinical effect of rosuvastatin combined with conventional therapy in treatment of coronary heart disease complicated with chronic heart failure.Methods:From July 2021 to February 2023,94 patients with coronary heart disease complicated with chronic heart failure who were admitted to Dongying City Dongying District Xindian Street Community Health Service Center were selected as the study subjects.They were randomly divided into the experimental group and the rou-tine group,with 47 cases in each group.The routine group was given conventional therapy,and the experimental group was treated with rosuvastatin on the basis of the routine group.The treatment effects were compared between the two groups.Results:The total effective rate of treatment in the experimental group was higher than that in the routine group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in left ventricular ejection fraction(LVEF),left ven-tricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)between the two groups(P>0.05).Af-ter treatment,the LVEF in the two groups was higher than that before treatment,and the LVEF in the experimental group was higher than that in the routine group,while the LVEDD and LVESD in the two groups were lower than those before treatment,the LVEDD and LVESD in the experimental group were lower than those in the routine group,and the difference was statistically sig-nificant(P<0.05).Before treatment,there was no significant difference in the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After treatment,the levels of hs-CRP,IL-6 and TNF-αin the two groups were lower than those before treatment,the levels in the experimental group were lower than those in the routine group,and the difference was statistically significant(P<0.05).Conclusion:Rosuvastatin combined with conventional therapy has significant clinical effect in the treatment of coronary heart disease complicated with chronic heart failure,and can improve cardiac function and reduce inflammatory reaction.