水凝胶调控巨噬细胞促进心肌梗死后心肌修复的研究进展

Hydrogel modulate macrophages to promote myocardial repair after myocardial infarction

心肌梗死(myocardial infarcti on,MI)是由于冠脉供血不足引起的心肌细胞坏死。坏死细胞诱发的炎症反应改变心肌微环境,并参与心肌损伤和修复的过程。巨噬细胞是炎症反应的重要执行者,通过不同亚型分泌不同功能的细胞因子参与心肌的损伤和愈合进程。调控巨噬细胞亚型已成为心肌修复的潜在治疗策略。近年来,水凝胶材料凭借其良好的生物相容性和功能化修饰能力,广泛应用于MI修复。功能化水凝胶不仅提供机械支撑,还可调控巨噬细胞亚型,改善梗死部位免疫微环境,促进心肌修复再生。本文对巨噬细胞在MI中的关键作用以及水凝胶如何调控巨噬细胞促进MI后心肌修复的现状进行综述。

Myocardial infarction(MI)is the necrosis of cardiomyocytes caused by insufficient coronary blood supply.The inflammatory response induced by necrotic cells alters the myocardial microenvironment and participates in the process of myocardial injury and repair.Macrophages are important executors of the inflammatory response and participate in the myocardial injury and healing process by secreting cytokines with different functions through different subtypes.Modulation of macrophage subtypes has emerged as a potential therapeutic strategy for myocardial repair.In recent years,hydrogel materials have been widely used in MI repair due to its good biocompatibility and functionalized modification ability.Functionalized hydrogels not only provide mechanical support,but also modulate macrophage subtypes,improve the immune microenvironment at the infarct site,and promote myocardial repair and regeneration.This article reviews the pivotal role of macrophages in MI and the current state of hydrogels in modulating macrophages to promote myocardial repair after MI.